( 1002 ) 
may bring about the division, a fact which was confirmed by 
J. Lous. 
The analogy between the effect of substances dissolving fat on 
the development of eggs on the one hand, and on the accelera- 
tion of phagocytosis on the other, may be carried on still farther, 
if we bear in mind that a copious action of these substances 
causes paralysis in the phagocytes (or destruction, as with cam- 
phor) and cytolysis in the eggs. 
4. It is a well-known fact that narcotics stimulate when applied 
in small quantities and only paralyse in greater amounts. Viewed 
in the light of the facts we have observed about phagocytes, the 
explanation is easy to find. 
At first, namely, the lipoid membrane of the cells is weakened, 
consequently the surface-tension grows less, and the rapidity of 
motion, the activity becomes greater. As soon as a greater amount 
of the narcotic has entered, its paralyzing effect on protoplasm 
becomes manifest. 
For some general considerations see p. 998 and foll. 
Groningen, January 1911. 
Physiology. — “On the stimulating effect of Chloride of Calcium 
and of iniestinal mucous membrane extract on the action of 
Trypsin.” By Mr. E. Hexma. (Communicated by Prof. H. J. 
HAMBURGER) 
(Communicated of the meeting of February 25, 1911). 
The investigation reported on in the following pages found its 
starting-point in an investigation relating to the question whether 
chloride of calcium possesses the property of activating trypsinogen. 
Several investigators, particularly LARGUIER DES BANCELS *), DELEZENNE *), 
Zunz*) and recently also miss Ayrton’) have attributed to calcium 
1) Lareurer prs Bancets. C. R. Soc. de Biol. 1895, p. 130. 
2) Deezenne. CG. R. Soc. de Biol. 1905, p. 476, 523, 614; 1906, p. 1070; 
1907, p. 274. 
5) Zunz. Annal. de la Soc. Roy. des Sc. Méd. et Nat. de Bruxelles. XVI. 1907. 
4) Miss B, Ayrron. Collected Papers. Inst. of Physiol. University College London. 
Vol. XV. Edited by KE. H. Srartine. 
