was engaged for some time on the investigation of the ‘dadap sub- 
stance’, but suspended the work after his departure from Java. 
In 1898 appeared a communication *) on hypaphorine, the name 
meanwhile given to the substance obtained from the ‘dadap seeds”, 
from the hand of Dr. GresHorr, in which, however, the results 
obtained by myself, were not included. 
In that communication are given the method of preparation of 
hypaphorine and also its properties. 
As regards its properties it may be mentioned here that hypa- 
phorine erystallises in hydrated transparent crystals, which effloresce 
in a desiccator. At 255° it melts without decomposition. On being heated 
strongly in the air it burns with evolution of vapours having an odour 
resembling indol. It has a right-handed rotation [alp=—= + 91°—98°. 
Although hypaphorine possesses a neutral reaction, it yields with 
acids crystallised compounds of which the sparingly soluble nitrate 
is particularly characteristic. No formula could be deduced from the 
recorded analyses of the hypaphorine and its nitrate. In the “Index 
Phytochemicus” by Rirsema and Sack, published in 1905, the formula 
C,, H,, N, 0, is, however, given for hypaphorine, but without any 
mention being made of the source. 
After the decease of Dr. Gresnorr, I applied to the Committee of 
the Colonial Museum at Haarlem with the request to forward me 
the preparations of hypaphorine from the laboratory of the Museum 
in order to enable me to continue the investigation, started previously 
at Buitenzorg. I have to tender my sincere thanks to that Committee 
for the great willingness with which, a few months ago, my request 
was complied with. 
The elementary analysis of the anhydrous hypaphorine gave me, 
at Buitenzorg, the following results : 
C 68.4; 68-4. Hi 10085008: N 10.9; 411.—. 
Calculated for Cj H,,N,O,; © 68:24, _ if 7505, be Naor 
The hydrochloride gave: 13.1°/, ; 18.1 °/, HCl. 
Caleulated for C,H. NO} MC. AID ENG 
On heating with strong aqueous potassium hydroxide, hypaphorine 
is decomposed. A gas having an amine-like odour is evolved and the 
aqueous distillate contains oily drops, which solidify after a while. 
The gas evolved was collected in dilute hydrochloric acid and the 
solid matter was separated by filtration from the aqueous distillate. 
The aqueous solution was united with the hydrochloric acid in which 
the said amine had been absorbed and evaporated. From the brown 
3) Mededeelingen uit ‘s Lands Plantentuin 25, 54 (1898). 
