43 
here. It should be stated that the stages of nuclear division were not 
nearly so well visible as with the mesentery. It was often difficult 
to make out what stage was present. Still it may be remarked that 
also in this case the two last stages of the process (chromatin at 
the poles and 2 young nuclei) only appear during the later hours 
of the cycle. 
Small intestine. Of the small intestine the epithelium of LirBeRKÜHN’s 
crypts was studied. It should be remarked at the outset that also 
in the adult intestine karyokinesis is always frequent. Still I thought 
that perhaps maxima and minima might be observed. 
The following table shows that this is indeed the case. Since it 
was impossible to make out here what stage was present, only the 
number of karyokinesis was counted. 
Time .of fixation | gece Or Number of karyokin. Percentage of the kar. 
101, a.m. 3070 58 | 1.89 + 0.25 
A Ne l 3086 | 60 | 1.94 + 0.25 
64 p.m. 3086 116 3.76 + 0.34 
101, p.m. 3093 127 4.11 + 0.36 
2!) a.m. 3043 87 | 2.86 + 0.30 
am. | 3076 73 | 2.31 + 0.27 
Distinct maxima are observed here at 6'/, and 10'/, p.m. (Here 
also both numbers lie again within the limits of the probable error). 
At 2'/, p.m. a decrease is clearly noticed; the minimum number of 
karyokineses is reached in the late morning hours and in the early 
afternoon. The lowest number is again observed at 10'/, a.m. although 
it cannot be stated, with certainty that this is the minimum, since 
the numbers of 7 a.m. and 2'/, p.m., as well as that of 10'/, a.m. 
lie again within the limits of the probable error. 
So the case is somewhat different from that of the two first-mentioned 
tissues. Here we have a continuous process, but as in the two 
former cases the maximum of mitotic nuclear division lies here in 
the evening and night. 
Liver. Finally preparations of the liver were thoroughly examined 
but without any result. Some very few distinct karyokineses were 
observed and many doubtful ones, but these were not such that a 
table of any trustworthiness could be based on them. Whether the 
