457 
ment of the ovarian connective tissue; the first because the normal 
rupture of eggnests into primary follicles failed to take place, and 
the last, because no primary follicles developed from the medullary 
cords. If this be true, the two kinds have also a different phylogenetic 
significance. The cord follicles arise from that part of the ovary 
which ought to be considered as the rudiments of the male part of 
the original hermaphroditic, sexual gland (Cf. Keren and Marr, Hand- 
buch d. Entwicklungsgesch. d. Menschen, part I, fig. 8). The ball- 
follicles are developed from the female part. Though the sexual 
cells in the rudimentary male part (the medullary cords) undergo 
exactly the same changes as the eggcells and afterwards actually 
lie in the real ‘vesicles’, it is yet possible that they are different 
from those developing in the female part of the sexual gland, (though 
this is of course not necessary). 
One might imagine that they will never develop into eggcells, fit 
for fecundation, and that the vesicles, containing such cells, become 
atretical. 
The follicles in the dog have generally more than one eggcell, 
but according to ScHMALTz the larger vesicles contain as a rule only 
one eggeell, and consequently Scnmaurz says the “mehreiigen Folli- 
kel” seem to disappear. According to Bonner (Lehrb. d. Entwick- 
lungsgeschichte, 1918) in multiparous animals, two or more eggcells 
are discharged at the ovulation. Bumm (Grundrisz der Geburtshilfe, 
12% Ed. p. 292), mentioning that STRASSMANN found in a human 
ovary two eggcells in nearly all the follicles, and even in the ovary 
of a woman, who died, while giving birth to twins, writes: ‘Da 
man bei Frauen, die nach Zwillingsgeburt starben oft nur em cor- 
pus luteum nachweisen konnte, scheint die Entstehung der Zwillings- 
gravidität aus zwei Hiern eves Follikels nicht einmal ein besonders 
seltener Modus zu sein”. Also, according to Keir. and Manu, vesi- 
cles with more than one eggcell may be the cause of twin gravi- 
dity. So it is very probable, that a number of follicles, with more 
than one eggcell, come to maturity and ovulation. But I wonder, 
are these not egenest follicles ? 
The following consideration led me to this conclusion: In an 
ovary of an infant of + months old, of which [ examined a 
series of sections, I found a great number of rather large folliculi 
vesiculosi and only some rests of medullary cords. Medullary cords 
are only seldom found in the calf (Mac Leop), on the other hand 
Hutz and Kapprniu found that shortly after birth, and even a short 
time before, a large number of well-developed Graafian follicles 
occur. This led me to the supposition whether these follicles, already 
