Physiology. — “On the Pharmacological Action of Lsoamylhydro- 
cuprem (eukupin) and Isoctyl hydrocuprein (vuziny’ By Prof. 
R. Maenus and U. G. Bisa. 
(Communicated at the meeting of April 23, 1920). 
Of late years especially three compounds out of a series of hydro- 
cuprein-derivatives, which had been examined by Morcsnrorn and 
his pupils on their antiseptic action in vitro and in vivo, have been 
applied in therapeutics. These researchers had namely discovered 
that the alkylated hydrocuprein-derivatives were strong antiseptics 
every member of this series having a specific affinity for certain 
micro-organisms. 
Thus ethylhydrocuprein counteracted especially pneumococci; 
isoamylhydrocuprein antagonized diphteria bacilli, bacilli of malig- 
nant edema and pyogenous cocci; isoctyl bydrocuprein neutralized 
the effect of bacilli of malignant edema and pyogenous cocci still 
more than isoamylhydrocuprein did (in vitro; in vivo they showed 
little difference). These three substances were given the commercial 
names, respectively of optochin, eukupin and vuzin. 
As most commonly happens with the products of chemo-terapeu- 
tie researches, also these three substances were applied to patients 
or to men under suspicion of being infected, before pharmacological 
examination had sufficiently established their effects upon the mam- 
mal. Indeed, with respect to optochin inquiries were made later on, 
but hardly anything was effected in this direction for eukupin and 
vuzin. In order to meet this deficiency as far as possible, we have 
examined pharmacologically the double-hydrochlorie acid salts of the 
latter two substances, which were put at our disposal through the 
kindness of Prof. Morcrnrorn (Berlin). Before long these experiments 
will be published’) in extenso in another place; for the present we 
are able to give a concise report of our results, in which eukupin 
and vuzin stand for the double hydrochloric acid salts. 
1. The pharmacological action of eukupin and vuzin (in the cases 
examined) agrees for the most part with that of quinine. 
2. Eukupinae bihydrochloridum is soluble in distilled water to 
1) For the bibliography we refer also to this detailed publication. 
