The following values obtained with normal animals without 

 injection of secretin are given for purposes of comparison : 



TABLE II. 



In some other experiments the effect of secretin on the amount 

 of sugar ill the blood was determined while the animal was sub- 

 jecled to the action of levo-rotatory suprareniii (Hochst). 



It is well known, that suprarenin has the property of producing 

 an excessive formation of sugar in the blood by splitting the glycogen 

 in the liver and of exciting glucosuria. By extensive experimentation 

 it has already been pointed out that the rise of the sugar-content in 

 the blood of a rabbit, injected subcutaneously with Ys "^g^"- of 

 suprarenin, amounts to about 100 "/o- ie. the percentage content of 

 the blood-sugar rises from ± 0.12.''/„ to 0.25— 0.30 7o in Vj, hour. 



The following table illustrates the results obtained, after I had 

 given the animal secretin intravenously five minutes before a sub- 

 cutaneous injection of V2 ingi- ^^ levorotatory suprarenin. 



TABLE III. 



12 

 13 

 14 



Date 



Secretin I Suprarenin 



Bloodsugar 



Urine 

 in 24 hours 



Jan. '12 



lice j 0.5 mg. 90 min. after seer. 0.205 0/0 

 16 „ „ „ t, )i )i II 0.151 „ 



13 „ I, M II I) II II '-'• IÖ' II 



58 cc ad 0.30/0 



120 

 60 





 0.6 



In the next series I extracted the distal portion of the ileum 

 instead of the duodenum and the proximal portion of the jejunum 

 and tried to detect whether this extract, which sliould be devoid of 

 secretin, none the less keeps down the percentage of glucose in the 

 blood, as well by itself as when acting concomitantly with supra- 

 renin. The results of four experiments, carried out in this way, 

 implied that this was altogether out of the question. 



From the foregoing experiments (18) we arrive at the following 

 conclusions : 



