8 



Using to some extent tlie action of levorotory suprarenin on 

 tlie sugar-content in the blood, but that, on the other liand, 

 this does not apply to the giucosuria, which, judging from the 

 values above mentioned, has a tendency to be relatively higher 

 with a reduced than with an increased amount of blood sugar. 



2. that injection of secretin seems to stimulate the activity of 



the blood from the pancreatic vein. 



3. that, to judge by some experiments, heretofore presented, 



(others were made which shall be dealt with in a later publi- 

 cation) the substance producing this action is thermostabile 

 and is soluble in 75 7» alcohol. 



Third Series (C). 



In connection with the preceding experiments the question suggested 

 itself as to whether the antagonism between suprarenin and the 

 l»lood from the pancreatic vein was to be looked upon as tlie out- 

 come of the action of a substance, which exalts the glycogenesis or 

 of one iidiibiting the gijcogenolysis. 



Concerning this point 1 purpose to publish some data afterwards. 

 For the present 1 feel called upon to bring forward two experi- 

 ments demonstrating the action of the blood from the pancreas on 

 the glycogen in the liver. It may be taken for granted that with a 

 dog in nitrogenous equilibrium every derangement in the process of 

 carbohydrate metabolism will also affect the N. metabolism in one 

 way or other. Two successful experiments are available (others were 

 l)erformed, which, however, did not always yield conclusive evidence) 

 actually pointing to a change in the N-metabolism. It was also evi- 

 dent fr®m all these tests that giucosuria is likely to appear, and that 

 in some cases traces of sugar occurred after the injection of blood 

 from the pancreatic vein. 



We present the data of the tests reported here in the following 

 table : (see table page 9) 



N". 36. The urine of a dog in N. equilibrium and weighing 

 5^2 KG. was tested for sugar every day, invariably with a negative 

 result. On the 23"^' of Dec. 30 cc. of blood from the pancreatic vein 

 was injected. Within 24 hrs two portions of urine were collected 

 (80 cc. reduced Fehling and yielded a positive fermentation test; 

 60 cc. reduced and yielded a positive fermentation test). 



N". 37. 30 cc. of blood from the pancreatic vein, liberated from 

 protein by 96 cc. of alcohol and evaporated down to its original 



