26 



1. If of 10 cc of blood 0.6 cc of serum is replaced by 0.6 cc 

 of an isoloiiic Na^SO^ solution, the amount of chlorine in the serum 

 is exactly the same as that which can be calculated beforehand from 

 the serum being diluted with a solution without chlorine. 



lite transfer of chlorine from the blood corjmscles to the serum, 

 found in people luith a normal chlorine-excretion, is, therefore not met 

 with in patients with cldorine-retention. 



2. If to 10 cc of blood 25 mgr. of crystallized Na^SO^ are added, 

 the chlorine in the scrum decreases. 



Hence the chlorine now moves in an opposite direction, if this 

 result is compared with the chlorine transfer, found in people with 

 a normal metabolism of chlorine. 



EXAMPLE. 

 Chlorine-transfer in the blood of patients with chlorine-retention, if 

 of the serum is replaced by isotonic Na2S04-solution, or 

 if solid Na2S04 is added to the blood. 



12"/, 



Chlorine in 4cc 



of normal serum 



corresponds 



with: 



lOccof 



blood 



contain: 



25 mgr. of Na2S04 

 having been ad- 

 ded to 10 cc of 

 blood the chlorine 

 of 4 cc of serum 

 corresponds with : 



Of 10 cc of blood 

 0.6 cc of serum is 

 replaced by 0.6 of 

 isotonic Na2S04 

 solution. 



The chorine of 

 4 cc of serum 

 corresponds with : 



If no chlorine- 

 transfer took place, 

 the chlorine of 4 cc 

 of serum would 

 in the latter case 

 correspond 

 with: 



4.87 cc of AgNOa 



5.5 cc of 

 serum 



4.59 cc of AgNOa 



4.34 cc of AgNOa 



5.5-0.6 



X4.87 = 



5.5 

 4.33 cc of AgNOa 



It seems that from the result of these experiments no other con- 

 clusion can be drawn, except that in patients with chlorine retention 

 a moditled permeability of the red blood-corpuscles is to be observed. 

 The question suggests itself if the permeability for the other body 

 cells has not also undergone a change. 



For the permeability of the red blood-corpuscles is verj' constant 

 if the chlorine-metabolism is normal. However ill the patient may be, 

 the permeability of the red blood-corpuscles is normal if the chlorine- 

 metabolism is normal. Now the patients with chlorine-retention show 

 a different permeability. This points to the fact that in this diseased 

 organism, influences have been active which have had a powerful 

 effect upon the permeability of the red blood-corpuscles. Since these 

 noxious influences have been able to change the otherwise so constant 

 permeability of the red blood-corpuscles, perhaps the supposition that 

 the permeability of the other body-cells has also been affected, is 



