'258 



whicli did not lead to diabetes even after 6 weeks, although the 

 venous hlood of this dog (see Exp. 34. Table V of the previous 

 publication) was competent to occasion a fall of the N-metabolism 

 in another dog in N-equilibrinm. 



Experiment 55. A little dog (4Vo KG.) had on the IS'h of June 1912 its pan- 

 creas (14 grs."» removed in the manner just described. The animal passed well 

 through the operation. The table on page 257 gives the history of the disease 

 together with the particulars worth mentioning. 



For want of further particulars 1 leave off tabulating. Suffice it 

 to say here, that glucosuria was increasing all along to as much as 

 40 grs. and more, that the N-metabolism was maintained constant, 

 that, however, on the l^t of July acetone appeared for the first 

 time and the animal was killed on July 4. The section brought to 

 light a small portion of the pancreas of the size of a die, which 

 looked unimpaired. 



All organs had exchanged their natural colour for a yellowish 

 white. This was due to strong lipemia, which made the bloodserum 

 creamlike. 



The effect of our injections is of course a matter of the highest 

 interest to us. From the values recorded above we may be justified 

 in deducing the following: 



The first injection of 35 cc. of pancreatic blood lessens the diuresis 

 and raises the glucose percentage to such an extent (from 6 to 107o) 

 that it cannot be a matter of mere chance. However, the N-percent- 

 age does not rise so much, so that D/N increases. For all this thei-e 

 is no augmentation of the quantity of sugar secreted on the day 

 itself nor on the two subsequent days. On the contrary it is slightly 

 lowered (15 — 11 grs.), which can neither be a casual fluctuation, 

 as for instance on the 18-'' of June, since the decrease continued 

 for more than twice 24 hours. This decrease coincides with a process 

 in the composition of the urine which is the reverse of the one 

 just mentioned, viz. an increase of the N-amount and of the diuresis 

 and a fall of the glycose-percentage. The effect of the second injec- 

 tion, on the 25'*' of June, is far less obvious, it is almost negative. 

 It is true, only 20 cc. is injected and the dog is subjected to a 

 slight narcosis with chloroform prior to the puncture of the vein, but 

 here a temporary rise of the glycogen-percentage is followed by a 

 fall ; the quantity of urine, however, first remains constant and in- 

 creases later on. Absolute decrease of the sugar secreted is out of 

 the question, rather the reverse takes place. Neither do we note 

 any favourable influence of ihe injection on the hyperglykemia. 



