200 



On tV.o 2cl of October i.e. only a fortnight after the operation the first traces of 

 sugar nppear. 'fhe substances j ust mentioned liave disappeared. 



Tlie following table gives particulars about the experiment with this animal. 



Retrospect. Here we have a case of a typical incomplete pan- 

 ci-eatic diabetes (Sandmeyeu). Not until a fortniglit after the extirpa- 

 lioii diabetes is gradually evolved and reaches its acme only after 

 three weeks. 



With regard to the injection of blood from the pancreatic vein, 

 obtained the previous evening under the intluence of secretin, we 

 notice an effect similar to that of the foregoing experiment. In the 

 first place a smaller cpiantity of urine associated with a i-ise of the 

 D-percenfage. As for the N-percentage the values are not very 

 demonstrative, because the urine had been standing for more than 

 24 hours. We could not make a reliable Kjeldahl-determination on 

 the most important day (Oct. 13). Still also in this case a relative 

 decrease seems to have occurred, succeeded by an insignificant 

 increase. 



Lastly it appeared again that after injection the total D-secretion 

 was for some days considerably lower than before. 



On the 'J9'^i of October the animal was sinking so fast, that sub 

 finem vitae D-secretion as well as N-elimination was retroceding. 

 On (his account the animal was despatched. 



At the section no considerable modifications (lipemia) were 

 detected ; owing to several adhesions nothing was to be seen of 

 residues of the pancreas. 



Experime'nt 59. In my judgment the following test yields weighty evidence. 

 The time of ob;invation was longer. Four injections of pancreas secretum were 

 given. 



In the ordinary way 20\/^ grs. of the pancreas of a dog is extirpated on 

 the 22d of September 1912. At a rougli guess 2 grs. is left in the abdomen. 

 Operation comes off quickly and without a hitch. As early as the 23d of Sept. 

 the dog takes water and milk. A trace of protein and a small quantity of sugar 

 is present hi the urine. On the 24th of September the dog is tolerably well, only 

 somewhat languid, vomits once more, l)ut eats some horseflesh and cake. A con- 

 siderable amount of sugar is present in the urine. The following table illustrates 

 our subsequent experience. 



Rett'ospcct. This is a serious case of diabetes, clearly demon- 

 strating the influence of different acts. The first two injections were 

 attended by an irregular secretion of urine on the preceding days, 

 as evidenced respectively by 8 and 17 grs. of sugar on the 27''^ 

 and 28 '' of Soplciubcr, which, when expressed graphically, yields 



