263 



tlie lips drew our attention; at the section it ai>i)eared that as well at 

 the lips as at the sublingual and buccal membrane these greyish white 

 protuberances wore visible and arranged symmetrically. Especially 

 in the sublingual membrane; symmetry was most pronounced at the 

 excretory ducts of the salivary glands. Thinking of the relation 

 betweeji the pancreas and the salivary glands we supposed this to 

 be a vicarious hypertrophy of the salivary glands. A microscopic 

 examination however did no.^ lead to detection of any glandular 

 tissue but only to a ranliling growth of the epithelium. 



CONCLUSIONS. 



A. The blood obtained under the influence of secretin from the 

 pancreatic vein is capable of lowering the total secretion of sugar 

 for some days, but also of raising the sugai'-{)ercentage temporarily. 



J3. The blood commonly evolves a relative fall of A'-elimination 

 close upon the injection, later on a i-elative rise. 



These experiences fall in with those recorded in our earlier publi- 

 cations. For instance the rise of the Z)-perccntage after injection of 

 blood from the pancreatic vein is in perfect concordance with the 

 fact that the same blood, thrown into normal dogs, also incites 

 glucosuria. On the other hand the influence on A^-eli mi nation in 

 dogs suffering from pancreatic diabetes, is just the reverse of the 

 influence in normal dogs. 



Critical summnry. A comparison of our results with those of 

 other researchers shows some notable differences. It is self-evident 

 that soon after the theor}^ of the internal secretion of the pancreas 

 had been jiropounded, efforts should be made to render pancreatic 

 diabetes less virulent by throwing blood of healthy dogs into dogs 

 suffering from the disease. Minkowski and Hedon were the first to 

 make the effort. Their failure strengthened Pflüger's contrary views. 

 Afterwards, indeed, some positive evidence was brought forward by 

 FoRSCHBACH ^), who, by application of the parabiosis between healthy 

 and diabetic dogs elaborated a decrease of sugar secretion. Ehrmann, 

 who also applied transfusion, failed again. Latterly similar experi- 

 ments have been made by Drenman ^) and Hedon •'). Drenman obtained 

 a very marked decrease of sugar secretion, after intravenous injection 

 of large quantities of normal blood. This blood, however, had lost 



^) FoRSCHBACH, Arcli. f. exp. Falli. u. Fharmat. Btl. IX, 1908. 

 2) Drenman, American Journal of Physiol. Vol. XXVIII, 1111. 

 ■^) Hedon, Refer. Dr. v. Herwerden. Neder). Tijdsch. v. Gencesk. 1013. 



