( 370 ) 



Here too where the food was not sufficient for the organism to 

 defray the costs of the muscular labour, as appeared also from the 

 increase of the nitrogen secretion on the workingda}^ one can cer- 

 tainly not speak of distinct influence of muscular labour on the 

 excretion of creatinin. 



It is howev^er different when no food is taken at all for days. 



Van Hoogeniiuyze and Verploegh had an opportunity to make 

 observations about this too on the "Hungerkiinstlerin" Flora Tosca 

 a strong, young woman, who lent herself for the investigation during 

 a starving period at the Hague, in a room which was opened to the 

 public night and (kiy. The urine was collected every day in three 

 portions, in the morning from 10 o'clock till 4 o'clock in the after- 

 noon, from 4 o'clock in the afternoon till 10 o'clock in the evening 

 and from JO o'clock in the evening till 10 o'clock the next mor- 

 ning; it was sent every day at a fixed time to the Physiological Labo- 

 ratory in Utrecht and was there examined at once. 



In the morning of June the 10^'' 1905 the last food was taken; 

 after that nothing but mineral water (Drachenquelle) till June the 

 25^''. Besides creatinin several other constituents of the urine were 

 determinated daily ; about this it will f)c sufficient to mention that from 

 the course of the secretion of nitrogen, urea, uric acid and phosphoric 

 acid it appeared sufficiently that no food was taken. 



During the whole hunger-period of fourteen days complete bodily 

 rest was observed as much as possible save on June the l?"^"^ when 

 Tosca during two hours with short rests, under direction of Verploegh, 

 was occupied with gymnastic exercises with halters of 1 KGr. 13 

 different movements were made, the first ten 20 times each, the last 

 three 10 times each. The movements were so chosen that as many 

 muscles as possible were set to work. 



The examination of the urine showed now that in hungering the 

 secretion of the creatinin as well as of the other products of meta- 

 bolism steadil}' decreased. But the muscular labour suddenly produced 

 an undeniable increase, not on the same day, but on the following. 

 Still on the third day the influence was to be perceived, which however 

 also was the case with connection to the total quantity of nitrogen. 

 On the first da}', when food was still taken, the quantity of creatinin 

 amounted to 1,087 gr. Later on it decreased rapidly and rather regu- 

 larly till on the 8^^^ day. On June the 17^^, the day of the muscular 

 labour, it amounted only to 0,469 to rise the following day to 0,689. 

 In the three days before the muscular labour 1,662 was secreted, in 

 the three following days 2,006 gr. creatinin. After that the secretion 

 decreased almost to 0,5 gr, daily, to remain rather constant then. 



