290 
than the strongest of the normal animal. After 20°/, blood has 
been withdrawn at least 60°/, new cells are formed. In this case too, 
the rule of Wericrrt, applicable in general pathology, holds good: the 
regeneration surpasses the loss by far. Only with regard to blood 
it cannot be deduced from the number of bloodcorpuscles, because 
for each new bloodcorpuscle an old one has to be disintegrated. 
Hence the absolute number of bloodcorpuscles per m.M*. can increase 
but slowly. 
Yet this strong regeneration of the blood-corpuscles too, has probable 
a beneficial effect upon the organism. Though there is no difference 
as regards size or haemoglobin-percentage, Morawitz has pointed 
out the fact that while blood in normal circumstances can bind 
chemically hardly any oxygen, the anaemic blood consumes rather 
large quantities of O,*). Hence the new blood-corpuscles differ 
qualitatively from the old ones, which appears besides from their 
increased capacity of resistance. 
6. Effect of the serum on haemolysis. 
a. The serum ts replaced by 0.9°/, NaCl. 
Before drawing the conclusions, mentioned above, 7 was necessary 
to determine the effect which the serum has upon haemolysis. Mostly 
we read that the serum contains substances which impede haemolysis’), 
for when the blood-corpuscles have been washed with 0.9°/, NaCl- 
solution, their capacity of resistance has decreased. If these substances 
were really present, it might have a considerable effect upon the 
capacity of resistance of anaemic blood. In anaemic blood there is 
relatively more serum than in normal blood: the greater quantity 
of serum would impede haemolysis more strongly, and this might 
give an impression of a greater capacity of resistance. 
It is indeed found that the capacity of resistance of the blood is 
lessened when it is washed with 0.9°/, NaCl. (See Fig. 4). 
b. The serum is replaced by 4°/, glucose. 
That this is not due, however, to the effect of the serum having 
disappeared, but probably to osmotic changes, follows from the fact 
that washing with an isotonic glucose solution (4°/,) does not modify 
the capacity of resistance (See Fig. 4). 
1) Morawrrz, Archiv f. exper. Pathol. u. Pharmacol. Bd 60. 
2) Gros. Ztschr. f. exper. Pathol. u. Pharmacol. Bd. 62. 
SATTLER l.c. 
