Pathology. — “On a micro-organism grown in two cases of un- 
complicated Malignant Granuloma.” By Ernestine pr Neerr and 
C. W. G. Mreremer. (Communicated by Prof. C. H. H. SPRONCK). 
(Communicated in the meeling of September 28, 1912). 
In recent years Malignant Granuloma, also called Lymphomatosis 
granulomatosa or Hopekry’s disease, has occupied the attention of: 
many writers and researchers, in consequence of which some more light 
has been thrown upon the subject after a long period of obscurity. 
For all this, the etiological evidence brought forward in the study 
of this incurable disease is still extremely limited. : 
In 1832, it is true, HopeKin') published the history of some cases 
and autopsies which may, to a certain extent, bear on the disease 
we are about to discuss, but its etiology was not dwelt on in the 
literature before many years later. 
_ No attempt whatever had been made to distinguish by differential 
diagnosis the various diseases, characterised by glandular swellings 
and enlargement of the spleen, until Vrrenow, in 1845, described 
leukaemia as a well defined disease. Next, in 1865, ConnHem distin- 
guished pseudoleukaemia as a disease of the lymphatic apparatus 
resembling leukaemia, but differing from it by the absence of the 
typical bloodpicture. Since Connarim the term pseudoleukaemia has 
again and again been misapplied to a congery of glandular diseases: 
others again added the epithet “tubercular” to it, so that in spite of 
Connneim’s discovery, the confusion was again as great as before. 
Neither did Birrrorn®) confine the term “malignant lymphoma”, 
a name often given to malignant granuloma, to one special affection 
of the glands, as he himself says in his paper on Multiple Lymphome. 
STERNBERG *) was the first to describe in an elaborate histological 
investigation a definite group of cases, thereby leading the way for 
later workers. He was likewise the first to discuss at length the 
etiology of the disease, as appears distinctly from the title of his 
publication: ‘Ueber eine eigenartige unter dem Bilde der Pseudo- 
leukamie verlaufende Tuberkulose des Lymphatischen Apparates.”’ 
However the etiology, suggested by the title, is not nearly ascer- 
1) 1832 Hopexin. On some morbid appearances of the absorbent glands and 
spleen. (Med. chir. Transact. Vol 17). 
4) 1871 Burrorn. Multiple Lymphome. Erfolgreiche Behandlung mit Arsenik. 
(Wien. Med. Woch. N°. 44 S, 1065). 
35) 1898 SrernBerG. Ueber eine eigenartige unter dem Bilde der Pseudoleukaemie 
verlaufende Tuberkulose des Lymphatischen Apparates. (Zeitschr. f. Heilk. Bd 
XIX S. 21). 
