Malaria 101 



and that quinine and vital vigour make for conditions 

 that form latency. 



The foregoing account, so far as it relates to the 

 clinical manifestations, applies only to uncomplicated 

 typical infections. Since there may be, and frequent- 

 ly is, an infinite variety as regards the number of 

 parasites present, different degrees of individual sus- 

 ceptibility, a concurrence of several species, or a 

 number of generations of the same species maturing 

 at different times, there may be a corresponding 

 variety of clinical manifestations, a detailed descrip- 

 tion of which, did space permit, would be, as Manson 

 has truly said, but an uninteresting and unprofitable 

 ringing of the changes on rigour, pyrexia, gastritis, 

 bone-ache, prostration, and other morbid phenomena. 

 The picture would be further confused by the fact 

 that the natural progress of the disease is generally 

 broken by the patient's use of quinine. 



Malaria and Anopheles. — Wherever the seasonal 

 prevalence of mosquitoes has been made the subject 

 of careful investigation, the period of greatest in- 

 tensity of malaria has been found to coincide with 

 that of the greatest prevalence of mosquitoes of the 

 genus Anopheles. It is not a disease necessarily 

 concomitant with a tropical climate. 



