UNIVERSITY FARM OUTBREAK. 265 
dullness, staggering gait and cold extremities. The skin was 
harsh and lacking sensation. This loss of skin sensation be- 
gan at the posterior extremities and gradually extended for- 
ward. The milk flow was completely checked or practically 
so in all cases. 
Second Period.—After 24 to 36 hours, diarrhea appeared, 
the discharge being dark and thin with very disagreeable 
odor. The breath in some cases was noticed to be very of- 
fensive. Nervous symptoms gradually developed and were 
very uniform in all cases. 
The symptoms during the second period were those 
which belong to a gradually developing nervous disturbance 
and were very typical of cerebro-spinal meningitis. The in- 
ability to walk naturally was continued, the gait being ir- 
regular and weak. The neck was usually bent to one side 
and the muscles, particularly of the face and neck, were 
spasmodically contracted. During this period the animals, 
with the exception of Countess, a large Holstein cow, were 
still quiet, moving around very little; ‘but the eyes showed a 
wild, unnatural expression. The skin continued to lose sen- 
sation progressively forward. Countess was continually 
groaning or rather grunting with each respiration; but not 
in evident pain. During this second period the animals com- 
menced to chew in a nervous and very persistent manner, 
with more or less profuse flow of saliva. 
It is also to be noted that the temperatures remained. 
normal or subnormal during this period. 
Third Period.—This was one of intense activity: The 
eyes continued to grow more wild and unnatural; the grind- 
ing of the jaws more active and more constant; the convul- 
sions of the face and neck muscles became more intense and 
then gradually a period of intense restlessness and activity, 
and death ended the scene in every case. 
Post Mortem Symptoms.—Several of these animals were 
examined and the symptoms as seen on examination post 
mortem were fairly uniform. 
Meningitis involving the spinal cord or brain or both 
these organs was invariably present. In addition to this 
there were hemorrhages involving the subcutaneous tis- 
sues, and lymphatic glands in various portions/of the body; 
