37'2 C. DA FANO 



when and where the absorption process is most advanced. In 

 such places, however, the degeneration of the tumour cells has 

 gone so far that they are hardly recognizable. 



In transitional zones like that shown in PI. 19, fig, 1, multi- 

 nucleated protoplasmic masses are now and then observed, 

 apparently due to the conglutination of a variable number of 

 degenerating tumour cells. Next to almost each of the nuclei 

 included in these pseudo-giant cells, typical remnants of the 

 apparatus are frequently seen with arrangements similar to 

 that described in connexion with a polymorphous cell sarcoma 

 of the mouse (see PI. xxi, fig. 29, of the previous work, 7). 

 A fusion of the apparatus of the single cells into a common 

 and centrally situated formation, as observed under different 

 conditions, was not met with in specimens from the Jensen 

 carcinoma. 



When the absorption process is nearing its end and the 

 connective-tissue proliferation leading to the formation of the 

 scar is very much advanced, the number of the carcinomatous 

 cells is very small, and these are recognized with difficulty, 

 particularly by the method used in this investigation. Never- 

 theless elements are now and then found which can be safely 

 considered as surviving tumour cells. Their identification is 

 chiefly based on the size and aspect of their nuclei and apparatus. 

 As shown by PI. 19, fig. 2, this has a much more robust appear- 

 ance than that of the other cells, most of which are large 

 wandering cells and fibroblasts mixed with a few leucocytes. 

 In some of the tumour cells the apparatus still possesses the 

 characteristic aspect to which reference has already been made ; 

 in others it is uncommonly large and looks like a somewhat 

 granular and disintegrating juxta-nuclear structure. The 

 apparatus of the connective-tissue cells is much smaller, 

 irregular in shape and structure, and often stretched in various 

 directions. 



T w r t . — The healthy cells of this tumour are provided 

 with an apparatus in the main smaller and more distinctly 

 reticular than that of Jensen's carcinoma. The changes 

 observed during absorption are similar to those above described, 



