GOLGI BODIES OF TUMOUR CELLS 378 



though a simple disintegration of the apparatus into a struc- 

 tureless material was the prevalent feature of many specimens. 

 A transformation of the apparatus into a large juxta-nuclear 

 formation was sometimes observed (PI. 19, fig. 3, iu.), but not 

 the fusion of various elements into pseudo-giant cells as in the 

 case of the Jensen tumour. 



In advanced stages of absorption of the Twort carcinoma 

 accumulations of large macrophages were found. Most of them 

 contained only formless debris of argentophile material, but 

 some possessed a small and irregularly shaped apparatus 

 (PI. 19, fig. 3, m.) situated close to the nucleus and on the 

 whole similar to that of the connective-tissue elements above 

 mentioned. 



Tumour 2 7. — The apparatus of the healthy cells of this 

 adeno-carcinoma generally consists of short rods collected in 

 a bunch on that side of the nucleus which is turned towards an 

 existing or virtual glandular lumen. Only in some groups of 

 cells it appears formed of reticular portions irregular in size, 

 shape, and distribution. In absorbing tumours of the same 

 strain the typical rod-like aspect survives only in a rather small 

 number of cells. Most of them either show the picture occa- 

 sionally observed in growing tumours or convey the impression 

 that the rods forming the apparatus have swollen into elliptical 

 or roundish shapes within which a minute light space can be 

 detected. It has been impossible to decide whether these 

 spaces are really empty or contain a material which does not 

 take the silver. PI. 1 9, fig. 4, is a good instance of this condition 

 which, in the specimens investigated, extended to wide areas, 

 easily distinguished from the unaltered tumour portions by 

 the pale colour of the nuclei. These showed in addition 

 a strong tendency to fuse into agglomerations in which the 

 boundaries between cell and cell could hardly be made out 

 even by very high magnifications. 



These observations were at first found a little surprising. 

 Other absorbing tumours of the same strain were therefore 

 carefully investigated, but with results which did not 

 essentially differ from those already obtained. The number 



NO. 267 c c 



