GOLGI BODIES OF TUMOUR CELLS 375 



appearance still survived in spite of the breaking up of the 

 whole structure into small portions and threads, only now and 

 then united by thinner filaments. 



Tumours 113 and 15 5.— The apparatus of the healthy 

 cells of these two carcinomata is very small and therefore less 

 suitable for observations of the kind considered in the present 

 paper. In the cells of areas undergoing absorption the apparatus 

 occurred, in both tumours, in the form of short rods or small 

 clumps closely arranged, one next to the other, on one pole of 

 the nuclei, but no structural details could be made out in the 

 intensely impregnated fragments. In more advanced phases 

 of absorption these fragments were still smaller and frequently 

 indistinguishable from formless debris. 



In conditions of this sort elements provided w^th a small 

 and well impregnated apparatus were often seen, but accurate 

 observations, particularly of serial sections, led to the con- 

 clusion that such elements were connective-tissue cells similar 

 to those shown in part of PI. xxii, fig. 32, of the previous work 

 and in PI. 19, fig. 2, of the present one. 



Tumour 630. — The regressive changes exhibited during 

 absorption by this squamous cell carcinpma are identical with 

 those previously observed in keratinizing areas of the same 

 tumour and need no further description. When absorption is 

 very advanced the tumours consist of small nodules of a more 

 or less completely keratinized material surrounded by a shell 

 of proliferated connective tissue in which a considerable number 

 of multinucleated giant cells are found. As shown by PI. 20, 

 fig. 8, some of them are provided with remnants of a centrally 

 situated and reticular apparatus, some only contain a finely 

 granular material, the granules being sometimes arranged in 

 such a way as to convey the impression that they also have 

 arisen from the fragmentation of a perhaps formerly reticular 

 apparatus. The presence of many giant cells in the above- 

 mentioned situation is probably due to the fact that in the 

 absorption phase in which they were noticed, nothing survived 

 of the old tumour but a hard substance in many respects similar 

 to a foreign body. The fragmentation of their apparatus may 



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