378 C. DA FANO 



the apparatus in certain growths (Jensen's carcinoma, tumours 

 206 and 91) has a striking similarity with Penfield's retisper- 

 sion (15, 16) and with alterations of the same kind observed 

 in degenerating nerve-cells by Battistessa (2, 3), Marcora (14), 

 Da Fano (8), and others. Some of the changes exhibited by 

 the apparatus in tumour 27 have an almost surprising resem- 

 blance with the modifications exhibited by the apparatus 

 in germ-cells as described by Gatenby (11) and his collaborators 

 Woodger (12) and Ludford (13), and more recently by Bowen 

 (5). The same applies to the changes noticed by Da Fano (9) 

 during the involution of the mammary gland at the end of 

 lactation. The phenomena described by the above-mentioned 

 authors and in the present paper were noticed in tissues so 

 different that no detailed comparison is possible. However, 

 they were worth brief mention because they seem to indicate 

 that the fragmentation of the apparatus, whether under the 

 influence of physiological or pathological stimuli, is up to 

 a point determined by the as yet obscure part taken by the 

 apparatus in various cell activities. 



Summary. 



In continuation of previous work the behaviour of Golgi's 

 apparatus during spontaneous absorption of transplantable 

 tumours of the mouse is described. In some of them the 

 apparatus soon becomes transformed into a granular almost 

 structureless material ; in others this terminal phase is reached 

 through stages which are probably determined by the charac- 

 teristic structure exhibited by the apparatus in the healthy 

 cells of the corresponding tumours. The modifications of the 

 apparatus during such stages have a striking resemblance with 

 the changes observed in different tissues under various physio- 

 logical conditions. The connective-tissue cells, which invade the 

 tumours as they are absorbed, are provided with a small, 

 irregular, and sometimes reticular apparatus w^hich is identical 

 wuth that described by other authors in similar elements though 

 in different pathological processes. In some of these elements 



