306 C. CLIFFORD DOBELL. 
behind when the brood of gametes swims off to conjugate. 
The whole of this residuary mass then dies. The same fate 
overtakes the remains of the microgametocyte in coccidiids— 
e.g. Adelea ovata, Himeria schubergi, etc. This 
does not indicate that the cell must be regarded as by nature 
containing two kinds of chromatin—somatic and generative 
—any more than it indicates that the cell by nature contains 
two sorts of cytoplasm. It simply shows us that a cell, or 
part of a cell, can get worn out with its life-activities and die. 
The residuum (Restkérper) is the corpse. 
This same idea has already occurred to R. Hertwig (06a), 
amongst others. 
Tr. 
And now to the hypotheses connected with chromidia. As 
Hertwig’s original conceptions of chromidia began with 
Actinospherium, and have been woven into his hypo- 
thesis of the karyoplasmic relation, I will begin with 
this. 
The hypothesis states that “ the relation of nucleus to pro- 
: k : 
toplasm, the quotient — that is, the mass of nuclear sub- 
) 
stance divided by the mass of protoplasm—is a constant, 
whose magnitude is of fundamental importance for all vital 
processes influenced by the nucleus, for assimilation and 
organising activity, for growth and division.”” Now, if nucleus 
and cytoplasm do not grow at the same rate, the nucleus may 
become too large for the cell, a condition which may lead to 
degeneration and death. ‘The nucleus, however, may reduce 
its size by giving up part of its chromatin—as chromidia— 
: : k a. 
and so re-establish the normal relation—. The chromidia 
are thus a means for regulating the karyoplasmic relations. 
The formation of chromidia by the macrogametocyte of the 
'T use this expression as an English equivalent of Hertwig’s term, 
“ Kernplasmarelation.”’ 
