AMG@BZ IN INTESTINES IN CASES OF GOITRE IN GILGIT. 735 
with one or other of those described in the preceding 
sections. 
The animal is usually spherical and of variable size, the 
forms most commonly met with averaging 15-20 jx in dia- 
meter. The protoplasm is sometimes divisible into a granular 
endoplasm with a thin layer of ectoplasm surrounding’ it. 
The ectoplasm is most obvious in these rare cases in which 
protrusions in the form of pseudopodia are seen. Often it is 
not very clearly marked off. The endoplasm is finely granular 
and contains extraneous matter; such inclusions as blood- 
corpuscles or epithelium have never been seen. I have not 
observed vacuoles. The nucleus in some cases is very difficult 
to see, presenting as it does staining reactions differing only 
a little from those of the protoplasm. It is frequently sur- 
rounded bya clear halo (text-fig. 19). It is very poorin chro- 
matin and does not appear to possess a karyosome. ‘There is 
nothing distinctive in the position of the nucleus; it may be 
central, but is more frequently excentric. It varies very con- 
siderably in size. Forms are commonly seen containing two 
or more nuclei (text-figs. 20,21). Multiplication is apparently 
very rapid, and takes place either by a process of simple 
division or by multiple division of the nuclei with budding of 
the protoplasm, examples of which processes are shown in 
text-figs. 19 and 22). This organism does not encyst as does 
Amoeba I. I have been unable to find that it develops 
cysts such as Schaudinn has described in E. histolytica. 
It is true that I have frequently found small, dark brown, 
spherical bodies in preparations where this was the only 
amoeba present ; their structure could not be made out, nor 
could it be shown that they had any connection with this 
amoeba. 
This organism resembles closely the E. histolytica of 
Schaudinn. There was, however, no evidence that patients 
whose feces swarmed with this Amceba were suffering from 
dysentery. 
I would also like to point out that the amceba here des- 
