422 



ill oihor words that liiere exists a immoral transmission'), I sav 

 "ill a still more com iiicin^ maiiiiei-", for by the Just mentioned 

 experiment the remark could lie made, that willi (he movement of 

 tlie second lieart hydrodvnamic influences might have pla3'ed a rrlle. 



Foi this reason for the second organ not the heail of the frog B 

 was taken, tint the stomach of this animal. 



It is well known that stimulation of the sympathetic nerve is 

 followed not only 1>3' an acceleration of the heart heal, lint also it 

 slows, even inhibits the sponlaneons movements of the stomach. 

 Now the question arose: if the (luid of the siimulated heart of 

 frog A is transferred into the arteria gastrica of the frog B, will it 

 then cause the spontaneous movements of the stomach of this last 

 frog to grow slower, even to stop? This proved to he the case, as 

 the experiments of Dr. Hkinkman and Miss van Dam showed us. 

 In other nwrd.s, o)i sipnpatlietic stlmulaiton of the first heart sub- 

 sttinces were liberated which influenced the movements of the stomach 

 in a:n, inhihilive way. 



Analogical phenomena as occur in stimulating the sympathetic 

 nerve could be observed by stimulation of the vagus nerve. 



As it is well known, stimulation of this nerve affects the rate of 

 the heart beat and also influences the strength of the contractions 

 of the stomach, but in an antagonistic sense. Stimulation of the 

 vagus slows the heart, but causes the contractions of the stomach 

 to become more powerful, conlrary to what happens when the 

 sympathetic nerve is stimulated. Now the experiment was re|>eated 

 by crossing (he circulation of the heart of the first frog with that 

 of the stomach of the second frog; in other words, the salt solution 

 coming from the heart of the first frog, is conducted to the stomach- 

 circulation of the second frog. On stimulating the vagus of the first 

 frog, the heart slows its beat and when (he solution has passed 

 111 rough this heart and reached the stomach of the second frog, 

 this organ shows typical vagal contractions, I hough the vagus of 

 frog B has not been stimulated electi'ically. From this we may 

 inter that stimulation of the vagns of the first frog sets free in its 

 heart vagus-substances, which may cause the stomach of the second 

 frog to contract, as if its own vagus nerve had been directly 

 stimulated. 



We are therefore in presence of two kinds of substances liberated 

 by the \ agus and sympathetic nerve respectively, which may be 

 called vagus- and sympathetic substances. 



I) R. Beinkman und Frl. E. v. Dam, Pfluger's Archiv. Bd. 196, S. 166, 1922. 



