82(5 



llie lyssavii'iis readies the central nei'voiis system along the nerves 

 as well as along tlie blood- or iynnphvessels. 



For the spreading of the virus along the nerves pleads; 



1"' the experiments of di Vkstka and Zagahi 



'2'"^ the experiments of Schaffer 



3''' that the blood has never been virulent 



[„Fast alle Forscher sind der Meinung dasz das Virus im Biute 

 nicht vorhanden ist" Koch, Band VIII, Koi,i,k, und Wasskrmann, 

 pag. 835]. 



4''' that subdural inoculation of blood from animals affected with 

 lyssa never causes the lyssadisease. 



Against the propagation of the lyssavirus along the nerves pleads -. 



1*' the ex|)eriments of Roux and Marik by which is proved that 

 only intradural and intracerebral inoculation ot lyssavirns gives 

 100°, positive results, whilst endoneural injeftion remains uncertain. 



The fact that the saliva of animals inoculated with lyssavirns is 

 most times virulent, would also plead against the propagation exclu- 

 sively along the nerves, if there were not the experiments of 

 Bkrtoreli.i. This author proved that one sided section of the nerves 

 innerxating the salivarv glands, shortly before an subdural injection 

 with lyssavirus prevents the infection o( the saliva at the operated 

 side. Moreover the fact that the saliva becomes viiulenl in the latter 

 part of the incubation, when the centi-al nervous system is already 

 infected, makes it possible that from the medulla oblongata along 

 Nervus facialis and Nervus trigeminus the infection of the salivary 

 glands takes place. 



We especially intended to see how far the histopathology of 

 lyssa agreed with the clinical and experimental facts mentioned 

 above. So : 



first : „lokether peripheric nerves have altered ami whether these 

 alterations may prove in farotir of a propayation along the nerve. 



secondly ; hoiv far a similar propagation of the lyssavirns persists 

 in the central nervous system and 



thirdly: irhether the nervous path to the salivary glands has altered 

 in such a way that these neiues may be considered as the medium 

 through which the virus reached the glands. 



To answer these questions and to make the histopathological 

 examination at the same lime as complete as possible we subdued 

 our material to different taxation and staining in a way as gives 

 the annexed scheme. (See Table following page). 



As soon as in the cornu Ainmonis A^ey/v'bodies were found and 

 besides the clinical fact there was also a histopathological [iroof, 



