829 



with a sliglil inagnificalion at first gave the impression that the 

 ceilgroiips had hardly suffered any loss. 



Transversal sections uf the adjacent 

 proximal part of the medulla showed the 

 following histopathulogical changes. All 

 the nei\etibres of the lateral columns of 

 the inoculated side are destroyed, the ante- 

 rior columns as well as the posterior 

 columns are partly destroyed, which de- 

 struction is continuous with tlie group 

 of degenerated fibres of the healthy side. 

 Pursuing the medulla spinalis proxi- 

 inally, if appears that mainly both the 

 lateral columns have a fatty degeneration 

 of their myelin but the posterior and 

 anterior columns too have some destroyed 

 fibres 



To value the alternations of the blood- 

 vessels in the peripheric lumbar nerves 

 and in the medulla spinalis was extremely 

 difficult. Prepared as we were by the 

 description in literature to find large in- 

 filtrations round the vessels and in the 

 tissue, to find hyalin lumps in the walls 

 of the bloodvessels, we were disappointed, 

 when searching for these clianges. 



The bloodvessels in our slices showed 

 a growing of their endothel and were 

 studded with blood corpuscles, we found 

 little haemorrhages in the peripheric nerve 

 and somewhere round the vessels. The 

 blood corpuscles however showed no trace 

 of fatty degeneration, the haemorrhages 

 GoLGi alteration in a nervecell proved to be of very recent date. So, 

 of tfie medulla spinalis. although the alterations of the blood- 



vessels were in accordance with the result of other authors, as 

 far as the degree of these alterations was coiu-erned, it was impossible 

 for us to place them above the changes of the nervecells and nerve- 

 fibres. The serious degeneration of the myelin sheaths, the loss of 

 the intracellular fibrils in the cells made it very probable that these 

 changes had preceded the very recent infiltrations round the vessels. 

 Toluidin |)reparations of the lower part of the medulla oblongata, 



Fig- V. 



