KM) 



Fig. VI. 

 Degeneration of myelin sljeaths. 



wiieie the miolei Nei\ i XII, Nervi XI and Neivi X are to be found, 

 offered a similar aspect of tlie state of tiieir ceils as is given b^ us 

 for llie cells of the medulla spinalis. In this part of the nervous 

 system iVf?</j'( bodies in the nervecoils were found. Plate I, Pig. J. 

 Tlie more proximal |)arl of the mednlla oblongata, the brainstem, 

 the cerebellnni and some parts of the braincortex were submitted 

 to different methods. 



In all those parts we found degenerated ravelin sheaths and c^lindre- 

 axes. The degeneration often consists in a iiimefaction of the myelin- 

 shealh and a loss of myelin, whilst the c.ylindreaxis is preserved 



lying in the middle of the hollow tube. 

 Fig. VI. No growing of iienrogliacells 

 along the destroyed sheaths was to be 

 seen. Changes of iiervecells of those parts 

 were of different degiee. The nuclei often 

 had the nio>l intensive changes. They 

 partly had lost llieii iiieinhrnne, were pale 

 and swollen with only a single nucleolus 

 stained red with eosine. Some times the 

 nnclens was diffuse stained, and scarcely 

 any sli'uciine was to be seen. 

 Silverproparations showed a granulation of the intracellularfihiils, 

 .some limes alterations as described by (Jolgi, the clotting together 

 of the fibrils were present. The impregnation of the extracellular 

 fibrils was some limes very coarse just as it is to be found in 

 Ai.zheimk.h's disease. This argentuphily of the tissue roiiinl the filn-ils 

 is perhaps lo be explained by the presence of a large (juaniity of 

 demolition products, reducing the silver nitrate. 



The Piirkiiije cells in the cerebellum had lost their Nissl lumps 

 and their intracelUdar fibrils, and were often only recognizable by 

 a partly deslroyetl nucleus in the neighbourhood of which .Vt'gri- 

 bodies were lying. Plate. I, fig. 2. 



The cells of the cornii Aiiruionis were the principal seat of the 

 yegri bodies, but our preparations gave no proof of these bodies, 

 being generally found in relatively healthy parts. In cells which 

 had scarcely undergone any change, as well as in (!ells totally 

 destroyed, these .^Ve(//7 bodies were present. For instance there was 

 a lack of ,V^<;(7bodies in the cells of the medulla spinalis; in the 

 brainstem and in the medulla oblongata, however we found a large 

 number of these bodies although the medulla spinalis as well as 

 the brainstem and medidla oblongata were the .seat of serious altera- 

 tions of the nervecells and nervefibres 



