831 



Benedek and Posche in their iiioiiograpliy as well as Fkan(;esco 

 ÜI Felice in iiis pii|)er dispute the parasitic nature of the A'e(//7bodies 

 and liotli these authoi's are fonxinced tliai fVagmenls of the nucleus 

 oF the ner\ecell take pact in the forniatiun of" these A^effrihodiei^. 



Touciiino' our matei-ial in this question we could slate that often 

 Negriboiiies were lying next to a quite normallj built nucietis, on 

 the other hand we found through the whole ner\()us s^ysteui changes 

 of the nuclei, that pleaded foi' ihe opinion of both authors. So we 

 found coarsely granidated nuclei, some of which granules entering 

 into the cytoplasma (Fig. VII). The Lenzniethoö, for the staining 

 of .Vtf^/-ibodies too demonstrated big granules in the nucleus assuming 



the same stain as the N^fffvi- 

 bodies do, whereas in normal 

 biains we did not find such 

 granules. Sometimes the whole 

 nucleus had assumed a diffuse 

 red stain (with Lenz method) 

 as if the different gi-annles were 

 dissolved. 



It was not our intention to 

 enter deeply into the question 

 concerning the nature of the 

 N^egr ibodies; curiosity however 

 stimulated us, when we treated 

 our slices of the cornu Amvionis, 

 rich in Negrihoè\e%, with nucle- 

 ase, in order to see whether these corpuscles as well as the nuclei 

 could be destroyed. 



Dr. VAN Hekwkkdkn was so kind as to teach us how to arrange 

 these experiments. The result was as shows Plate 1, fig. Ill that 

 only skeletons of the nucleus were visible aftei' the experiment, but 

 that Ihe AVf/r/bodies had obstinately resisted the resolving power 

 of Ihe nuclease. They had kept the same form and stain as the 

 iVf^c/bodies which were ireated with boiled nuclease that had lost 

 its destructive power. Plate 1, Fig. IV. 



But these negative results do not exclude thai the iVg(/?7'bodies 

 are built tVoin material of the nucleus, especially by oxyphile ele- 

 ments, which aie not destroyed by the nmdease. Oui- experiments 

 only pleaded for the fact that the chroniatine elements of the nuclei 

 |)robabIy do m(M take part in the formation of these bodies. 



As we had al our disposal section as well as fixation of our 

 malerial. we succeeded in (he impregnating of the Goi,(ii apparatus 



Fig. VII. 



Granules from the nucleus entering tlie 



cytoplasm. 



