41 



circulation, cliemotactic properties of definite substances do not come 

 into play. The process of tlie emigration is the same, whatever may 

 be the nature of tiie substances injected for the purpose of obtaining- 

 the exudation in the abdominal cavity. Neither can any special 

 significance be attached to fat and lipoids. 



2. As for the chemical composition of tiie obtained exudation, it 

 appeared that in a short time it becomes about the same as that of 

 the normal tissue-fluid. 



3. The injected fluid very .wo7i reaches a higher degree of acidity 

 relative to the blood and the normal tissue fluid; independent of its 

 being acid or alkaline when ijijected, a concentration of hydrogen 

 ions of about pH 7,2 is produced, while the normal reaction of 

 blood and tissue-fluid is 7,6. 



4. This higher acidity must be considered to be ansiuerable for 

 the emigration, since the emigration stays aioay, lohen the acid re- 

 action is checked. 



5. In keeping with this fact also in inflammatorj^-abscesses, the 

 reaction of the fluid relative to the blood is distinctly more acid. 



6. It is possible to consider the emigration as resulting from the 

 potential diflerence arising under the influence of the difference in 

 concentration of H-ions between the blood and the injected fluid, 

 in the sense of a cataphoretic action. 



7. We call attention to the possibility, that also in other abnormal 

 accumulations of leukocytes in the body, as in leukaemia, corre- 

 sponding factors play a part. 



February 23, 1922. 



From the Fhy.siological Laboratory of the 

 Groningen State- Univ. 



