Bio-chemistry. — "Changes in Milk clue to Sterile Inflammation 

 of the Udder." Bj Prof. B. S.tollema and J. E. van der Zande. 

 (Communicated by Prof. C. Eykman.) 



(Communicated at the meeting of May 27, 1922). 



The examination of a number of samples of abnormal milk from 

 cows suffering from clinically observable affections of tiie udder, 

 as well as from cows in which clinically no anomalies of the 

 udder were noticeable, impressed us in J 921 with the idea that 

 too great an importance is ascribed to streptococci as causative 

 agents of the secretion of abnormal milk. We found for instance 

 that in very abnormal milk streptococci are often absent.^) We, 

 therefore, decided to go further into this subject and produced 

 sterile inflammation of one of the quarters (R. F.) of the udder of 

 a milch-cow in full lactation, with the aid of a suitable injection. 

 On the suggestion of Prof, Paimans a solution was administered of 

 of silver-nitrate of 0,2 V.. ') 



In the same cow a sterile abscess had previously been developed 

 through injection of oil of turpentine in the region of the neck with 

 a view to ascertain whether such a sterile inflammation exerted 

 any influence on the secretion of milk. We were induced to do so, 

 because in a previous investigation in our laboratory anomalies had 

 been found in the milk yielded by animals which were affected by 

 inflammation of quite other parts of the body than the udder. 



The results obtained after the injection of oil of turpentine need 

 not take us long. Although a considerable abscess had developed, 

 the composition of the milk did not undergo a notable change, 

 neither during the development, nor after the abscess had become 

 mature. 



Once the sediment of the milk from orie of the quarters had 

 increased a little, of which the abscess may not have been the 



') Our report pertinent to the matter in question appeared in Tijdschrift voor 

 Vergelijkende Geneeskunde enz. Band 7 1922. 



*) We were in a position to prosecute this inquiry thanks to the aid of Prof. 

 W. J. Paimans and the Conservator for Obstetrics, Mr. J. A. J. M. Kirch, whose 

 assistance we acknowledge with gratitude. 



