368 



gives few particulars liowever, so thai I did not lliink it superfluous 

 to re|)eat this experiment. Il appears thai quite different processes 

 may arise, dependent on the lapse of time between tlie application 

 of the two driif'S. 



A. If veratrin is first injected and the application of en rare is 

 put off till a distinct veratrinogram appears, the curare-injection 

 remains without perceptible effect, the veratrin-poisoning proceeds 

 as usual. 



B. If curare is injected either simidtaneously with veratrin-or 

 so short a time after, that the veratrin-efFect has not yet become 

 manifest in the shape of a curve, in the fui-ther course of the experiment 

 a typical veratrinogram appears, which shows that the two parts 

 are equally effected by curare, so that both of them diminish till 

 complete indirect insensibility; on direct stimulation the muscle even 

 then gives a typical veratrinogram. 



C. If veratrin is applied, if there is already an outspoken curare- 

 poisoning, no veratrin-offect is shown, the poisoning behaves as a 

 common curare-action till complete indirect insensibility. 



D. If veratrin is injected while there are slight effects of the 

 curare-action — it is of course impossible to mention objective data 

 on this subject — in the further progress a veratrinogram appears 

 with a usually ver}' striking second top, wich is afterwards modified 

 into a normal-looking veratrinogram, which further behaves as such. 



jE". F'inally veratrin may be injected between the stages C and 

 D; then there arises neither a rapid contraction nor a veratrino- 

 gram, but a muscle-contraction, which should be identified the 

 second shortening of the veratrin-curve. On direct stimulation there 

 is also formed a typical veratrinogram in that case. (Fig. 2). The 

 further process may lead to complete indirect insensibility, or to 

 the fact that before this slow contraction there occurs a rapid one, 

 causing another typical veratrinogram. In shape the shortening thus 

 obtained is identical to the second contraction of a veratrinogram, 

 when this succeeds the first in isolated condition, as it is sometimes 

 seen during a poisoning-process. 



Examined on a quick-turning cylinder its latent period appears to 

 be twice or four times as long again as that of a normal single 

 contraction ; no top is formed, the highest part of the contraction is 

 a horizontal line; the crescent is much less steep than the decrescent ; 

 the duration amounts to one to four seconds. 



3. Temperature. .i:;i;/(ii 



As to the influence of temperature, I agree in general with Brünton 



