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large dosis of morphin to some patients, after a few days a dosis 
of seopolamin, and again some days later half the dosis of each 
poison. In control-experiments, some patients were first given the 
morph. + scopol. and afterwards the two poisons separately. In all 
cases the administration of the mixture resulted in a general narcosis, 
which did not occur after morphin or scopolamin alone. This then 
is a case of true “potentiation”. 
This finding does, however, not yield great profit for the clinic, 
since this result is not always obtained and, as to sensitiveness to 
scopolamin, patients differ too much to render a correct dosage 
possible. 
Summary. 
Morphin produces a narcotic effect in rabbits, in dogs (and also 
in men), but the curve representing the relation between dosis and 
effect is a parabola, which means that with the smaller doses 
a small increase in the doses causes a considerable increase in 
the narcotic effect, whereas with the larger doses a similar increase 
of dosis brings about a much smaller increase of the narcotic action. 
Scopolamin narcotizes the rabbit. The concentration-effect curve 
concurs with that of morphin. Its stimulating effect is obvious in 
the dog, in man its action is evidently narcotic. 
No “potentiation” is obtained in the rabbit with the scopolamin- 
morphin mixture, either by our reflex-method or by HauckoLp’s 
method. Neither was “‘potentiation” dedected in the dog. 
According to SCHNEIDERLIN “potentiation” occurs in man, but it is 
presumably not constant. 
