. 441 
kept in horseserum at a low temperature, retain mobility for days, 
we now proceeded as follows: 
A certain number of loops were severed from the fresh small 
intestine, which had been cautiously cleaned with Tyrode solution; 
their movements were registered by Macnus’s method. The vessels 
containing the loops were filled with 75 c.c. Tyrode solution of 38°C. 
When small quantities of atropin (0,002—0,01) were added, the 
pendulum movements of the loops got invariably smaller. 
This is illustrated in Fig. 1. 
Fig. 1: Q Fig. 2. Fig. 3. 
15 mg. Atropin 
0.01 Atropin 15 mg. Atropin 0.01 Atropin 
Fig. 1. 
Pendulum movements of the rabbit’s small intestine suspended directly after 
killing the animal. By administering 0,01 mgr. of atropin the magnitude of the 
movement is reduced by half. 
Fig. 2. 
The loop whose movements are registered here is the same as in fig. 1. The 
previous action of the atropin (0.01 mgr) is entirely eliminated through washing 
three times with Tyrode solution. 15 mgr. of atropin now yields a strong inhibi- 
tion on the movements while the tonus is only slightly lessened. 
Fig. 3. 
A loop of the same gut, standing for 3> 24 hrs. in the refrigerator in horse- 
serum that was repeatedly refreshed. Subsequently the loop is washed out eight 
times with warm Tyrode solution and no longer reacts on 0.01 mgr. of atropin. 
After 15 mgr. of atropin a marked stimulation appears together with a conside- 
rable increase of tonus. 
After this the loops of intestine were washed out with fresh Tyrode 
solution three times every 10 minutes, by which, as we know from 
our Own experience, the effect brought about by the preceding small 
atropin-dosis was again completely eliminated. 
When thereupon a moderate dosis (15 mgr.) of atropin was added, 
the pendulum movements became considerably smaller in far and 
29* 
