444 
small atropin-dosis yielded a mueh weaker inhibition on the peri- 
stalis than with the first loop. 
Subsequently another loop was examined, which had been kept 
standing in Lockrs’s solution some hours longer again, and had 
been washed a few times more ete. 
Table | comprises the results of the complete experiment. 
From it we see that the gut, which is arrested by quantities of 0,1, 
1, and 5mer. of atropin, is brought after a 25 hours’ washing with 
Lockr’s solution into a condition in which O,1 and 1 mgr of atropin 
produces a much weaker inhibition, 
TABEE A: 
Critical interior pressure in mm H,O. 
Number 
Time of : 3 SS 
of the loop EEE | | 
‘ atd 8. \after 0.01 mgr. after 1 mgr. after 5 mgr. 
we normal. |. of atropin. of atropin. « of atropin. 
| 
| 
1 0 Tie Inhibition Inhibition Inhibition 
2 25 20 25 30 Inhibition 
| Quick 
3 6 20 16 20 ‚20 pendulum 
movements. 
4 8 12—16 13 — | — 
5 11 10 7 = = 
After the process of washing had been prolonged for 6 hours the 
inhibition of these atropin quantities had entirely stopped, but now 
peristalsis appears after 0,1 mgr. of atropin already at a lower 
interior pressure as in the normal period. Also with loops of intes- 
tine that have been washed 8 and 11 hours atropin causes distinct 
stimulation, so that peristalsis comes forth already at a lower interior 
pressure. 
With loop N°. 3 a very considerable increase of the pendulum 
movements was also perceptible after 5 mgr. of atropin. 
It has thus been proved also for the small intestine of the guinea- 
pig that the inhibition of atropin, already established by TRENDELENBURG, 
can be arrested by washing and that the atropin-action proper, 
stimulation of AurrBacn’s plexus, can be elicited by small quantities 
of atropin. 
Now it is obvious also why TRENDELENBURG noted only the inhi- 
bition of atropin. It was because he did not allow the loops to 
stand in a solution, but always experimented with fresh ones taken 
from the guinea-pig under urethannarcosis. 
