631 



When, after an injection of atropin, a decapitated cat is subjected 

 to a series of injections every time of the same amount of nicotin, 

 the subsequent increases of the bloodpressure are relatively equal, 

 as one of the present writers has pointed out. ^) The amount of 

 nicotin, injected every time., must be small: from 01 to 0.2 mgr. ; 

 larger doses bring about before long a paralysis of the sympathetic 

 ganglia, while no rise of the blood pressure is evolved. The same 

 occurs when more than 8 or JO small injections have been 

 administered. When, after the 2"^ or 3'^ nicotin injection a similar 

 quantum of lobelin is injected, a rise of bloodpressure reveals itself, 

 as high as the rise after the nicptni, as shown in Table I. 



TABLE I. 



The effect of 0.1 mgr. of nicotin compared with that of 0.1 mgr. 

 of lobelin, after the injection of atropin. 



P rise of the blood rise of the blood 



t.xpe . pressure after 0.1 nicotin pressure after 0.1 lobelin 



The concordance between nicotin and lobelin need not surprise 

 us as Dreser *) and Edmunds ') have shown before that lobelin and 

 nicotin act similarly on many organs The quantitative concordance 

 between the two substances could not be surmised, especially also 

 because the structural formula of lobelin is not known. The empiric 

 formula was given as C\jHj^ON(?). 



If, however, nicotin is injected before lobelin, and after this another 

 similar quantity of nicotin, the rise of bloodpressure after the latter 

 amount of nicotin is much higher than that occasioned by the former 

 (Cf. Table 11). 



M W. Storm van Leeuv^en, Geneeskundige bladen 19e reeks N^*. 5. 

 ») Dreser. Arch, fur exp. f^alh. u. Pharm. Rd, 26, page 237, 1890. 

 ') Gh. Edmunds. Americ. Journ. of physiol. vol. XI, page 79, 1904. 

 Gh. Edmunds. Journ. of pharmacol. and exp. therap. Vol. I, page 27, 1909. 



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