635 



wil! have to furnish an explanation for the phenomenon in this and 

 in other cases. It is remarkable thouoh, that in the case nnder 



C.05 ai 



1— 



6 5 



Fig. 2. 



Relation of the amount of lobelin to the influence 

 exerted by lobelin upon the rise of blood pressure after 

 0,1 mgr. of nicotin; 



abscissa: amount of lobelin in milligrammes. 



ordinate: difference in nicotin action before and after 

 the lobelin injection, expressed in mgr. Hg. 



discussion a potentiation has been found in a mixture of two sub- 

 stances, no doubt pharmacologically closely allied, and on that 

 account should, according to Bükgi's preconceived idea, 7iot display 

 the phenomeno]!. 



In conclusion we wish to say that we do not ignore that the 

 tinctura lobelin is seldom prescribed in Holland, but it is used i-ather 

 largely in other countries, so that this potentiating effect upon Jiicotin 

 (and maybe also upon other drugs, not investigated' by us) has 

 also its practical side. 



