(217) 
of bromine or nitrous acid) four of the acetyl groups must be 
distributed over the five hydroxyl groups of the glucose. The sub- 
stance, however, could not be higher acetylated either by acetic 
anhydride or acetyl cloride. 
The derivative obtained by benzoylation of glucose-ureide proved 
to be the tetrabenzoyl compound (m.p. 117°). 
Of the substituted wreas and other amides the following have been 
investigated as to their behaviour with glucose in dilute sulphuric 
acid solution and found to give: 
change in the rotation. no change in the rotation. 
methylurea symm. dimethylurea 
asymm. dimethylurea »  diethylurea 
phenyl urea »  diphenylurea 
benzyl urea _ (asymm. diphenylurea) 
thio urea acetamide 
biuret benzamide 
urethane glycocol 
guanidine 
alanine, leucine, taurine. 
Some of the compounds glucose with substituted ureas have been 
isolated and their properties appeared to be quite analogous to those 
of glucose-ureide. 
Of the different sugars whose behaviour towards urea has been 
investigated, only those appeared to react which possess an open 
carbonyl group such as the aldopentoses and aldohexoses; of the 
bihexoses: lactose and maltose. Ketoses, however, as shown by 
experiments made with fructose and sorbose do not react with urea. 
The ureides of galactose, mannose and lactose have been isolated. 
Mannose-ureide has a different composition, as shown by the amount 
of nitrogen C, H,,0;.N .CO. NH, + Co Hy, Os. It reduces not only 
FeHLine’s solution but also BARFOED’s reagent but does not yield 
with phenylhydrazine acetate the phenylhydrazone of mannose. 
Lactose ureide has a much greater crystallising power than the 
ureides of the hexoses and could, therefore, be readily isolated from 
the products of the reaction without removing the excess of lactose 
by fermentation. The composition of lactose-ureide is 
Cy. Haa 01, .N . CO. NH, + Ho O 
and its properties are analogous to those of glucose-ureide. 
A full report of this investigation which is being continued in 
different directions will appear in the “Recueil”. 
