(744) 
of erepsin on albumose and peptone, COHNHerM has not been able 
to determine, aad we also have refrained from such investigations 
at present, not knowing for how long the juice of the patient would 
be at our disposal, and to be able to answer other questions, which 
demanded less time and did not seem less important. 
III. Secretion of the intestinal juice. 
The quantity of intestinal juice from the loop varied under normal 
circumstances from 50 to 125 ec, averaging for the 66 days during - 
which our observations were made 88 cc. in the 24 hours, the 
morphological elements included. This quantity is much larger than 
that which was obtained by previous investigators. To know whether 
there were variations in the course of the day, the patient was 
requested to collect the juice for a given length of time every three 
hours and each time to put it into a different bottle. This method of 
collection could not however be carried out during the night (8 p.m. 
to 8 a.m.). 
This was continued for 19 days, and when the volumes obtained 
in the same periods were added together it was found that the largest 
quantity was collected in the evening between 5 and 8 o’clock. | 
If we compare further what was collected during the day between 
8 a.m. and 8 p.m. and that which was obtained during the same 
period of time in the night, then much more was obtained during 
the night (1027) than during the day (766%/,). 
We cannot draw any very definite conclusions from these figures 
because it was impossible to ascertain exactly how the intestinal loop 
was situated; it is not improbable that, in a lying position, a certain 
quantity could flow down, which was retained in a standing, sitting 
and walking condition. 
The difference between the periods 2—5 p.m. and 5—8 p.m. is 
striking. This difference indicates that there are besides the intest- 
inal lumen, still other factors which inflnence the quantity of the 
secretion. 
SCHEPOWALNIKOFF found that, with dogs, the secretion of the 
intestinal juice was of a purely local nature. To excite secretion 
a caoutchouc tube had to be inserted for a considerable distance 
into the intestine through the fistula, otherwise not a drop of intest- 
inal juice was excreted; a glass tube similarly inserted was not a 
sufficient stimulus. 
In a later communication we hope to speak of the influence of 
different physiological conditions on the quantity, composition and 
