100 PUBLIC ABATTOIRS AND THE PREVENTION, ETC. 



are the cases of scrofulous p^lands in the neck, of tubercular 

 peritonitis without intestinal ulceration, and cases of so-called 

 remote tuberculosis, "primary" tubercular meningitis, or 

 tubercular disease of the joints and bones. The experimental 

 study of the disease explains in great part the anomalies in the 

 distribution of the lesions in the human subject. A single dose 

 of tuberculous material given with the food of a healthy pig 

 will, if large enough, produce intestinal ulceration, subsequent 

 infection of the mesenteric glands and of other glands in the 

 abdominal cavity, followed by a general infection of the body. 

 A smaller dose will produce no ulceration or sign of infection of 

 the mucous membrane of the intestine, but will produce enlarge- 

 ment of the mesenteric glands, and perhaps affect no other part 

 of the body." This important fact, namely, that a small dose 

 of tuberculous virus may infect the internal organs of the body 

 without producing a lesion in the mucous membrane by which 

 it IS absorbed was well illustrated by many experiments of the 

 Royal Commission. From a practical point of view, the repro- 

 duction of scrofulous glands in the neck was as important as 

 any of the results. Thus Avith a large dose of tubercular virus 

 given to the pig ulceration of the tonsil might result, with 

 infection of the glands below the jaw, and then a general 

 infection of the body. With a smaller dose there was no 

 ulceration of the tonsil, but the glands below the jaw were 

 infected, and subsecjuently the glands of the neck, and then the 

 lungs. With a smaller dose in one case, and also in a calf, the glands 

 below the jaw were alone affected, there being no affection of the 

 tonsil or of the body generally. The second and third classes of 

 experiment reproduced cases which are continually occurring in 

 human beings, namely, scrofulous glands of the neck, occurring 

 either by themselves or associated with tuberculosis of the lungs. 

 After the administration of a large dose of the poison the disease 

 progressed gradually, but with certainty. It is not unfrequently 

 seen with smaller doses, that the disease, after infecting one or 

 the other parts, appears to remain stationary for a long time ; 

 but even when remaining stationary for months the lesions 

 produced are still infective, as is frequently seen in the human 

 subject. These lesions may lead to a generalization of the 

 disease. Too much stress cannot be laid on this point as an 

 explanation of the cases of so-called remote tuberculosis. In 

 some of these cases in man — such as cases of tubercular 



