152 



a ininiimim. The muscles show a strong inclination to contractions. 



At the same time the respiration shows a pei'iodicity that is 

 known by the name of Oheijne-Stokes' respiration. Groups of dyspnoea 

 alternate here with pauses. In Fig, 1 we see curves of this 

 phenomenon wiiich were I'egislered b}' suspension of the skin in 

 one of the Hanks. During the flank-movements the pharj'iigeal 

 respiration continued likewise and in such a manner that after each 

 flank-movement a movement of the month-bottom could be observed. 

 In the pauses both these movements ceased. 



The curves of Fig. 2 were registered with another frog by placing 

 a cork cylinder through which a pin had l)een pierced, on the back. 

 The up-and downward movements of this cylinder were enlarged 

 by a lever-system and registered on a drum covered by smoked 



Fig- 2. 



pa|)er. The flardc-movements were here likewise accompanied by 

 movements of the month-bottom, wdiilst in the pauses both these 

 movements ceased. In both figures we see in the beginning of the 

 groups the ascending degree indicated. The periodic respiiation was 

 succeeded by a cessation of the respiration. This cessation was 

 reached, after the animal had remained about 24 to 25 hours in 

 the hyperisotonic solution of Ringkr. 



I found likewise a constantly occui-ring deviation at the eye-lenses. 

 The surface of the pu[)il had the appearance of cataract. 



The phenomena enumerated above were caused by the increase 

 of the osmotic pressure of the liquids of the body. A few more 

 controling expei-iments were made in this respect. 



Whilst the periodical respiration was still gohig ou, or likewise whilst 

 a cessation of the respiration had ab'eady set in, the frog was put into 

 the water. After the animal had been in the water for 24 hours, all the 

 phenomena mentioned above had disappeared. The frog was then 

 again quite normal, the passivity, the reflectionlessness and coma 

 had entirely disappeared. The respiration was then again noi-mal, 



