560 



Retention capability of l<idney for a mixture of 0.1 % glucose and 0.1 o/o 



sacch. lactis (lactose). 



Experiments of September 24—26. 



Reduction 

 perfusion liquid 



Reduction urine Retained Reduction urine Retained 

 of by of by 



rigiit kidney right kidney left kidney left kidney 



Froe A ^■^^''^' 



^^^^ ^ 0A6 \ 



Frog B 



Frog C 



Frog D 



Frog A 0.16 o/o 



Frog B „ 



Frog C „ 



Frog D „ 



0.0825^ 

 0.0825^ 



0.09 / 

 0.095 \ 



0.09 



0.1 



0.096 



0.10 



0.104 



0.096 



0.0925 



0.0765 % 



0.065 „ 



0.0675 „ 



0.06 „ 



0.064 „ 



0.06 „ 



0.056 „ 



0.064 .. 



0.0825/ 

 0.0825^ 



0.095 U 095 

 0.095 r"^" 



0.0925 



0.104 

 0.10 

 0.094 

 0.10 



0.076 % 



0.065 „ 



0.065 „ 



0.056 „ 



0.056 „ 



0.066 „ 



0.060 .. 



considerable time has been made of lactose for clinical use to estimate 

 the validity of" kidneys and which is fonnded on the consideration that 

 the healthy kidney easily passes lactose. 



We thank Mr. R. Rokt, ink for his able assistance dnring this 

 research. 



Swum art/ and Conclusion. 



1. The fact, now again affirmed, that, when we pass a Ringer's 

 solution to which glucose has been added, through the kidney, 

 this is retained by the glomerulus membrane, while salts, which 

 are also crystalloids, are allowed to pass, has raised tiie question to 

 what this contrast must be attributed. 



2. In the first place we can tiiink of the circumstance that 

 glucose possesses a so much larger molecule, which could then impede 

 the passage. If this hypothesis be correct then the disaccharides such 

 as saccharose, maltose and lactose, which possess a still larger 

 molecule (Ci^H^^On) than glucose (C\Hi,0,), would certainly not pass 

 through. Experiments have however proved that the glomerulus 

 epithelium is permeable to a large degree to these sugars, eve7i to 

 raffinose (C.^H^^O,,). 



The permeability to lactose is perfect. 



