( 85 ) 



and Moork') we should not neglect the value of these phe- 

 nomena. For the absence of the compensatory pause (Wenckebach) 

 finds in the above interpretation its complete explication. At the 

 same time we can now regard Hering's opinion, that all pulsus 

 bigemini should always depend on extra systoles as definitively 

 rejected. 



With Fonke I agree finally in this that a further discussion 

 about the question, whether apart from the pulsus alternans also the 

 existence of a pulsus bigeminus must he acknowledged, is completely 

 superfluous. On the other hand it might be desirable, it' the experi- 

 mental results of' Knoll and those of Hering in warmblooded animals 

 about hemisystolia and heart-trigemini, should be taken up again, 

 also in regard to the recent anatomical data. 



Regarding these questions three recent researches must be 

 regarded as important, firstly the observations of W. EiNTHOVEN 

 whose accurate illustrations also of partial contractions, appeal- to 

 promise a good deal for further analysis. Moreover the important 

 researches of Tawara : ') in Aschhof's Laboratory, which has shown, 

 how far the division of functions in the ventricle of the warm- and 

 perhaps also of the cold-blooded animals has gone. 



Finally the observations of Mackenzie* who lias shown us the 

 possibility, to get information also in man about the movement of the 

 auricle under pathological circumstances, so that we may expect 

 also this field of work becoming fertile for scientific analysis. 



The next thing should be, to bring also the sinus of man under the 

 scope of the graphical method. Wenckebach 6 thinks to have reason 

 to believe, that dissociation of the sinus described by me in lower 

 animals *) might be observed equally in men. 



To physiology the task to examine what influences are able 

 to dissociate the two principal bundles of the "Reizleitung" system 

 and to get information about nerve influence as well regarding that 

 system itself as upon the muscular mass of the ventricle. 



') Hay and Moore. Lancet L906. p. 1^74. 



2 ) Einthoven. Tijdschr. v. Geneesk. II. No. 22. 



s ) Tawara. Da^ Herzleitungssystem. l'J06. 



'J Mackenzie. Britisch medical Jul. 1902. Nov. p. 1411. 



"j Wenckebach. Arch. 1'. Physiologic. 1906. p. 361. 



6 ) American Journal of Physiology. Vol. I. 1898. No. IV. p. Ö03. 



