568 



F. A. E. CREW AND HONOR B. FELL 



(2) It may soak betweon the peripheral epitlieHal cells into 

 the iiitertubular tissue and stimulate; the connective-tissue cells 

 to an increased production of white librous tissue. Such a condi- 

 tion is connnonly met with in cancer and other pathol(jgical 

 states in which colloid or nuicoid degeneration is in progress. 

 The white hbrous tissue is usually laid down around some 

 solid structure such as a tubule or an aggregation of cells. 

 This is the; condition in the human. 



The colloid may follow both courses in the same testis as 

 in the case of the goat and the rabbit. 



Stone, in his paper on a pseudo-hermaphrodite goat/ men- 

 tions a ' layer of hyaline material ' within the basement mem- 

 brane of the tubules. Doubtless this is of the same nature as 

 the structures we have described. 



Inter tubular Tissue . — As in the goat, the intertubular 

 tissue is present in large quantities. It is composed chiefly of 

 white fibrous tissue and interstitial cells. The bundles of 

 fibrous tissue divide the gonad into a number of small com- 

 partments in which lie the interstitial cells. 



The interstitial cells are well developed and very numerous. 

 The cell-limits are distinct. The cytoplasm is granular and 

 contains a large circular nucleus of finely granular structure. 

 A nucleolus is present. The interstitial cells appear to be in 

 rapid proliferation in certain areas in wliich numerous mitotic 

 figures are seen (PI. 21, fig. 15). In places the interstitial cells 

 seem to be undergoing a remarkable metamorphosis (PI. 21, 

 fig. 16). The cytoplasm increases in volume and becomes more 

 granular, while the nucleus takes up an eccentric position. The 

 cytoplasm finalh' increases to about t-s\-ice its original size, 

 and the nucleus is situated at the extreme periphery — it may 

 even cause a slight bulging of the cell wall. Such cells are 

 usually formed in patches which are clearly demarcated from 

 the surrounding tissue. The}' may, however, occur in small 

 groups in which the various stages in the transformation can 

 be followed. It Avould appear that the granular cells are fat- 



^ R. S. Stone, " Atypical Male Sex-eusemble in the Domestic Goat ", 

 ' China Medical Journ.', v. 34, November 1920. 



