( 35 ) 



As besides trypsin, otlier on/.vinos liave foine to mii' know Icd-jo 

 whicli ai-c also soci-ojed w lien in a |»r('liniinar\ sl;iuv. it is prcrciaMc 

 as is fi-('([nenlly done now, not 1o speak here of "/.n nioLicn", Imi of 

 "I ry iisinouen' (a- "|)rolryj>sin". 



From (lie \ ery ix'^inninu' lli<' (jneslion arises wheilier llie lilieralion 

 of llie ternieiit takes |»lace in tlie liland or in the intestine. Accor- 

 diii,!»: to researches made Im ('amis uiid (ii,K,v') ainl I)i;i,i',zi;nm', "), the 

 latter is nsnally the ease; aeeordinu' to Poimi',i,ski ') alwavs. 



Tiien tiie second (luestion arises: In what way does the /ihciutddn 

 ill tliA' iiiicduK' talce i)lace? 



Until a lew years a.U'o this liheratiii'i' action was solely ascribed to 

 the acid of the gastric jnice. 



Intlnenced by i-esearches made in I'.vwi.ows laboralory. allenlion 

 lias of late been di-awn to the intestinal Jnice "). 



As thei-e appeared to be two ways that miuht ellect the liberation 

 of try|)sin, it was important to know, what relative valne c(»nld 

 be ascribed to each of them. 1 have therefore inade the action of 

 acids, amongst others also of hydrochloric acid, a subject of close 

 investigation. 



Tracing the c<>mminiications in literature in respect to the inllnence 

 of acids on the liberation of trypsiji, one is always being directed to 

 the publication of 1\. Hkidknuain, just mentioned. When \\v examine 

 these writings we lind that scarcely a page has been dedicated to this 

 problem. Oidy the method, by means of which 11i:iui;mi \i.\ lia> 

 obtained the result, is shortly referred to, positive experiments are not 

 described however. He (uihj nu'iitloiis, tkat, irlwii iw IukI iirrlrcd a I 

 the end of Ills iitr('.st((/((fioii.->\ Iw found flint ijhia'i'un'-i'.vtrncls from 

 in(n<'r('<issiihst<in<:i' ojn'mte iiuicli iinn't' clfecfuwli/ when tin' tilninl- 

 .snhstnncc /.y niitwil iritli (KU'tLC-. ncnK Ix'ftnw (jhiccrun' is ndilt'd : nn 

 ohscrrntlon inlUck navi't' faded in nnij of dw cnscs n-licn In' n jijiln'd 

 this met hod. 



When a man like lli',ini''-Mi vin |)nblislies his oltserv atioiis, we ha\c 

 to take them into account, even aithongh (he experiments are not 

 |)ublislied along with (hem. In dilferent (ex(- and handbo<d<s and 

 monographs, we Hud i-elaled that acids possess (he jtowcr (o ellec( 



1) Camus and (ii.Kv; Dklkzen.nk. C. K. Sue. df Hiul. blV. (I'.IOii). 

 -) L. Pfji'iKL.sKi, Ucht'i- tiie Grundeigen.scliallen dos Paiikieassalles. ( Iciilialld. lïir 

 Physiol. U Mai 10u;i 



=') N. P. Sianoi^owALMKuw, Diss. IVlcisbuig 18*.M); Pawujw, Das ivxpci iniinl. 

 Wiesbaden DJ(X), p. 15: Walthki;, Archives Hal. de Biol. I'.tOl. 



H. .1. ft.v.MBLHUKK aud 1<3. Hkkma, "On intestinal juice <»C man." Üipnil Knyal 

 Academy oi' Sciences P.>()2, p. 71:5. 



3* 



