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temperature oxaljlpiperidide, with aniline oxanilidc, with o-uitraniline 

 oxalyldi(o.nitraniline), with /M-iiiiraniliiie oxalyldi(y/?.-nitraniliiio) and 

 with /;iiitraniline oxaljldi(p-iiitraiHliiic). 



With 1.2.4 dinih-aniline no action was noticed at the ordinary 

 temperature ; here it was necessary to boil and benzene was used 

 as solvent. This led to the formation of oxalyldi (1.2.4 dinitraniline). 

 In these circumstances, no reaction was obtained with trinitraniline. 



It was further shown that in the case of oxalylchloride we can 

 also work according to the method of Hartwig Franzkn and make 

 use of the hydrochlorides of tlie amines. On boiling these in benzene 

 with oxaljdchloride until the evolution of hydrogenchloride ceases 

 oxalylderivatives are readil}^ obtained. Apart from the advantage 

 that the hydrochlorides are more readily ])rocurable, this method is 

 also more convenient in so far as that less of the amine is required 

 and that the reaction proceeds quietly and no special precautions 

 are necessary. 



I noticed this with the hydrochloride of aniline which gave oxanilide 

 and with that of piperidine vv^hich gave oxalylpiperidide. 



To the amines belong also the esters of the amino-acids and I 

 endeavoured to obtain ^) oxalylderivatives from their hydrochloric 

 compounds by the last mentioned method which succeeded very 

 readily, for instance with the hydrochloride of glycocollethylester 



CONH CH,COOC\H, 

 when oxalyldiglycocollethylester | was obtained 



CONH CH,COOC,H, 

 in beautiful needles melting at 143°. A similar result was obtained 

 with the hydrochloride of glycylglycinethylester. This yielded 



CO Nfi CH,C()NHCH.,C00C,H3 

 oxalyldi(glycylglycinethylester) | in 



CO NH CH.CO NH CH,COOC,H, 

 beautiful lustrous leaflets melting at 250°, which exhibit the so-called 

 biuretreaction. 



Already a few other hydrochloric compounds of the amino-acid 

 esters have been treated in the same manner with an equally good 

 result. Such as that of the methylester of «.aminopropionic acid 



1) The above mentioned metliod of Hartwig Franzen could also be successfully 

 applied to the preparation of tlie cliloroucetyl derivatives of the esters of the amino- 

 acids. On boiling diloroacetylchloride dissolved in benzene with the hydrochloride of 

 glycocollesler I obtained chloroacelylglycinethylester and with the hydrochloride 

 of glycylglycinethylester chloroacctylgiycylglycinethyleslcr. Both with a very good 

 yield so that this method deserves the preference to that employed by FiscnER 

 for obtaining thi) chloroacetylderivalives of the polypeptides as well on account 

 of the better yield as of the less complicated metliod of working. 



