( 313 ) 



was daily examined from 8 to 12 and from 12 to 3 separately. On 

 those days (8 — 12) remarkably little creatinin was excreted during 

 the tonus, while the quantity in the period of 12 — 3 increased con- 

 siderably. On those days the average amount per hour was: 



July 6, 8—12 (during the tonus) 51.7, from 12—3, 82 mgr. 

 Q 48 9,^ 



J) *^5 »> J) 5> J) ^^^ JJ >> '-'»J ,, 



>> 15, ,, ,, ,, ,, 52.5 ,, ,, 95.5 ,, 



5> 18, ,, ,, ,, ,, 5o ,, ,, <8 ,, 



on the other days the average excretion was: July 6 — 19, from 

 8_12 60.6, from 12—3 75.6 mgr. 



More than the ordinary amount of urine (235 cc.) and at the same 

 time more creatinin (74.3 mgr. per hour) was excreted in the first 

 period of July 12, after a walk from 8 — 12, but during the rest 

 of that day the creatinin did not exceed its usual limits, as the 

 above figure of the total excretion shows. 



Corresponding to the series of experiments by Van Hoogenhuyze 

 and Verploegh the average excretion of creatinin per hour was 

 found to be less during the night than in the day time. And as a 

 rule the figure of excretion was still low in the first period of the 

 day from 8 — 12. For the whole series, from June 20 to July 20, 

 excluding the tonus-days, it amounted to : 



from 8 — 3 on an average 65.6 mgr. per hour 

 3—10 ,, „ 67.6 



,, 10 — 8 ,, ,, 57.7 ,, ,, ,, 



Undoubtedly a considerable part of the creatin, formed during the 

 muscular tonus and passed into the circulation, was not changed 

 into creatinin and excreted as such, but was further decomposed. 

 However this is not evident from the total amount of excreted nitrogen 

 which is subject to fluctuations, dependent on numerous unaccountable 

 circumstances, notwithstanding the uniform nourishment and the 

 regular way of living. 



If we compare the products of decomposition of creatin to the 

 nitrogenous matter of the urine being of an other origin, they occupy 

 but a secondary place. In this series of experiments about 1.5 gr. 

 creatinin was excreted per daj', equivalent to about 0.5 gr. nitrogen, 

 i.e. a small part of the total amount, about 13 gr., which was per 

 day found in the urine. Over against the nitrogen produced by the 

 protein, that is digested in the alimentary canal and afterwards is 

 desamided, the increased production of creatin in the tonus cannot 

 possibly be of much influence, eAen though we must take it for 



