( 314 ) 



granted that the creatinin excreted by the kidneys, represents only 

 a part of this creatin. Yet, stating the average excretion of nitrogen 

 and creatinin per hour, tlie fact is remarkable that on the tonus- 

 days the proportion of the amount of nitrogen to that of the creatinin 

 is largest in the afternoon in the period of 3—10, after the creatinin 

 has reached its maximum in the preceding period. 



So the above experiments confirm the conclusion, drawn from the 

 content of creatin in the muscles of vertebrates, that chemism in the 

 muscular tonus is totally different from that in the contraction of 

 the muscles. In the first case a nitrogenous metabolite, creatin, is 

 formed, in the second non-nitrogenous products are consumed. 



In performing mechanical labour the influence of the tonus is 

 greater proportionally to a more or less careful control of the move- 

 ments. Consequently we might admit the supposition that intense 

 muscular labour will produce an increase of the excretion of nitrogen, 

 if not only powerful contractions are called forth, but the movements 

 are regulated with great care by tonic contraction of the antagonists, 

 as is often the case with athletic performances. 



Physiology. — ''The effect of substances which dissolve in fat on 

 the mobility of Fhagoci/tes and other cells." By Prof. H. J. 

 Hamburger and J. de Haain. 



The investigations which will be described in the following treatise, 

 are a continuation of those published in the Proceedings of March 

 25th 1911 '). 



It will be remembered that their starting-point was formed by 

 an investigation relating to the favourable effect of Iodoform on the 

 treatment of wounds, and that we arrived at the result that even a 

 slight quantity of this substance (a dilution of 1 to 5000000) has the 

 faculty of accelerating the amoeboid motion of the white blood- 

 corpuscles and of promoting at the same time their phagocytarian 

 capacity. In order to explain this i)roperty of Iodoform we assumed 

 that the outer layer of the phagocytes consists of a fatty (lipoid) 

 substance. Now when Iodoform is dissolved in it, this fatty substance 

 is softened and the amoeboid motion is facilitated. If this view was 

 the correct one, then other substances, soluble in fat, such as Choro- 

 form, Chloral, Benzene, Camphor, Turpentine must likewise increase 



1) Hamburger, de Haan and Bubanovig : On the influence of Jodoform, Chloro- 

 form and other substances dissoluble in fats on Phagocytosis. 



