1292 
A hurtful effect of anions of H, even in much greater concen- 
trations than those in which ‘he anion was used in the propionic 
acid experiments, is evidently out of the question. The propionate 
1: 25000 and 1:100000 leave the phagocytarian power intact; 
propionic acid in this concentration destroys all the leucocytes. 
But what is much more remarkable than this result ís the favour- 
able effect of still higher concentrations of propionate (1: 100; 
1: 250; 1: 1000) on phagocytosis. 
By dissolving for instance 1 gramme of propionate in 250 cem. 
of NaCl 0.9°/, the phagocytosis is found to increase by 100 °/,. 
This increase, which was also caused by the Na-salts of butyric 
acid and formic acid, was all the more remarkable, as the fluid 
was made strongly hyperisotonic by the addition of these soaps, and 
as was shown hyperisotony has nearly always a highly injurious 
effect upon phagocytosis. 
This is clearly confirmed by the following experiment in which 
isosmotic NaCl-solutions, with and without propionate, are compared 
with each other. 
The comparison relates to the following isosmotic solutions: 
NaCl 0,9°/, and NaCl 0,9°/, 
NaCl 1, °/, „ NaCl 0,9°/, + Na-Propionate 0,165°/, 
NACI a7) his) NRO OP jen heey 0,23") 
NaChdeo5) ss IMAGO BE en 0,5 °/ 
NaCl: 9h. en NGE seen 0,66 °/, 
These fluids acted for half an hour upon fresh leucocytes ; then 
TABLE III. 
Effect of isosmotic NaCl and NaCl-Propionate-solutions. 
Percentage of NaCl-solution 0.99, Percentage of 
Solution | leucocytes having | leucocytes having 
| taken up carbon a | taken up carbon 
| | 
Nac10.90/, | 1925 100 = 28.20, nothing 88 100 = 25.50 
a | AGS Ti 266 eg 
> aie SS 400 = 247 > Na-Propionat 016500 | 22 100 == 12.9» 
157 == 24. ropionate 0. 0 325 =e 
62 ) 113 
sld ap se » 0.33 >| 376% 100 = 35.9» 
69 | 193 
> 422 ages ee et » Olan 32 643 * 100 = 30 D 
| 
16 bs | 116 zt 
» 1233 979% 100 = 2.2» » 0.66 > zog < 100 21.1» 
