( 363 ) 



off quickly and our experiments began at the earliest, an hour after 

 the cessation of the narcosis. 



As for our experiments, a discussion of the influence of ether can 

 therefore have no ■value. 



It was a different case, with the small quantity of morphia which 

 we injected four hours before the beginning of our experiments. 

 Our reason for doing so was partly to keep the dogs a long time 

 quiet (insensible to pain), partly to use its influence for the stimu- 

 lation of the cortex as morphia increases the irritability of the psy- 

 cho-motor centres to a certain extent. 



The influence of morphia on the respiration was evident in all 

 the tracings we obtained of our animals. In consequence of the very 

 moderate dose of morphia which was used, the respiration may be 

 somewhat slower and deeper than before, but (and this is a charac- 

 teristic feature in the tracing of the respiration in morphinised dog:?), 

 every now and then, in some cases frequently, the regular tracing 

 is interrupted by a quick and very deep inspiration, followed by a 

 slow and prolongated — a suppressed — expiration (Fig. 1). 



This long and deep sigh which we called the morphia-sigh, we 

 always met with in the tracing of the respiration of morphinised dogs.. 



Sounds in the neighbourhood, e. g. the clapping of hands, the 

 rattling of the hammer of the induction- apparatus, may call it forth. 

 Often, in the majority of cases even, it seems to come, without any 

 exterior influence. 



Another irregularity, which is closely connected with the typical 

 one we described, is the following: 



Short inspirations, not very deep, but quick, are noticed in the 

 tracing, during the prolongated expirations, characteristic to the sigh. 

 They change the aspect of the sigh. It seems, as if a secundary type 

 of respiration with a quick rhythm, is superimposed upon the ordinary 

 type. This superposition may be seen at the very first in the expiration- 

 phase of the morphia-sigh, but often the quick respirations appear in 

 the expiration-phase of several respirations, sometimes even in every 

 one of then. (Fig. 2.) 



Both changes, the deep inspiration with lengthened expiration, 

 and the quickened respiration, at first only noticeable during the 

 period of expiration, speak in favour of increased inspiratory functions. 



They are of the same nature as the inspiratory effects, observed 

 during the excitation of our point 1(5 of the frontal part of the 

 cortex '). As we mentioned before, it is known that morphia increases 



ij (;. Winkler 1. o. p. IDS and ti'r. XXV, XXVII ;iiid XXVIII. 



25=" 



