( G75 ) 



rically contradicted from various sides. (Cohn 1 ), Remlinger 8 ), Basset»), 



Küss et LoBsTEiN 4 ), Beitzke 6 )). 



Some of the above mentioned considered the normal anthracosis 

 in test-animals as a source of mistakes, which Vansteenberghe and 

 Grisez had nol taken into account whereas others described the 



aspiration also as a source, which might give rise to wrong con- 

 clusions. 



Meanwhile Vansteenberghe and Grisez, supported l>v Calmette •) 

 maintained their opinion. They explain the negative results of their 

 opponents in the following manner: some allowed too much time to 

 pass between the introducing of carbon particles into the stomach and 

 the killing of the test-animals, because after 48 horns the pigment 

 would have almost completely disappeared from the lungs; others 

 used rabbits or too young cavies as test-animals, in which the fine 

 particles are almost wholly retained by the mesenteric glands. 



With a view to this last remark I wish to publish the following 

 experiments, because I have taken into account the age of test- 

 animals as well as the time which passed between the introduction 

 of the fine particles and the killing of the animals. 



To me it also appeared that the physiological anthracosis is a 

 factor which must be considered, for among all my test-animals, 

 cavies as well as rabbits, black pigment was found in the lungs. 



Among some animals this spontaneous anthracosis was rather 

 decided, with others very minute. As a rule there was much less 

 pigment in the lungs of my rabbits than in those of the cavies. 



The physiological anthracosis impedes as a matter of course the 

 experimenting with black substances. Besides carmine, vcrmillion 

 and ultramarine, I have also used Indian ink and soot, because after 

 microscopic investigation it appeared that the first mentioned matter, 

 even after being intensively rubbed in a mortar, was not as fine as 

 the particles of carbon of the last mentioned. 



In order to control the experiments of Vansteenberoiik and Grisez 



i) Berliner Klin. Wochenschr. 1906, N» 44 und 45. 



2 ) La Semaine médicale, 1906, N° 45. 



3 ) La Semaine médicale, 1906, N' 47. 



4 ) Bulletin medical du 21 Novembre 1906. 

 La Semaine médicale, 1906, N" 48. 



5 ) Virchow's Archiv, Bd. 187, Heft 1. 



6 ) Gompt. rend, des séances de l'Académie de Sciences, T. 143. p. 866. 

 Gompt. rend, de la Soc. de Biol. T. 61, p. 548. 



La Semaine médicale, 1906, N () . 50. 



