( 878 ) 



change of the nucleus in its entirety, in the vast majority of cases a 

 distinct amitotic disintegration is observed, the number of fragments 

 varying, but generally lying between three and live. As the already 

 modified nucleus dissolves into these fragments the comparability 

 with poly nuclear leucocytes seems more obvious, and the colour as 

 a rule approaches more and more to that which the blood-corpuscles 

 themselves assume in the artificially tixed preparation. The same fact 

 was stated by me also for Tarsius in 1898 and figured on PI. 14 

 figs. 91—96. 



Finally I point out, since my results and those of Poljakoff agree 

 in so many respects, that also Retterer in the volume for 1901 of the 

 Journal de l'Anatomie et de la Physiologie (Structure, développement 

 et fonction des ganglions lymphatiques, p. 700) has obtained similar 

 results and is inclined to assume a still closer genetic relationship 

 between polynuclear leucocytes and haematogonia when he declares 

 that the leucocytes, liberated from lymphatic glands "finissent par 

 se convertir, dans la lyinphe ou Ie sang, en hématies grace a la 

 transformation hémoglobique de leur noyau..." 



Thus my observations on Galeopitheous form a link in the chain, 

 which begins with Heinricb Muller in 1845 (Zeitschrift für rationelle 

 Medicin vol. •">. p. 260) was then continued ami upheld by Wharton 

 Jones (Phil. Trans. 1846, p. 65 and 71) and Huxley 'Lessons in 

 Elementary Physiology, 1866, p. 63) and which, since in 1898 

 Tarsius added another link, has with increasing weight bound up 

 the question of the origin of the non-nucleated blood-corpuscles in 

 mammals to the conception that these elements in the mammalian 

 body are not equivalent with cells, but must be regarded as nuclear 

 derivatives. 



(May 24, 1907). 



